Opening of rod #photoreceptor CNG channels by photodynamically generated singlet oxygen. New study from Gaogao He, Lei Zhou and colleagues (Shenzhen Bay Laboratory): rupress.org/jgp/article/...
#Biophysics #MolecularPhysiology #IonChannels
Left: This image visualizes the precise retinal mosaic formed by ultraviolet-sensitive cone (red) cells in zebrafish, highlighting the organized cellular landscape that underlies this research. Right: This image highlights the abundant cone population in the adult zebrafish retina, with UV-sensitive cones distributed throughout the tissue. The visualization, achieved using the Tg(sws1:GFP) transgene to label UV cone cell bodies. Creator: Jingjin Xu.
#Photoreceptor cells vary in the morphology of the light-absorbing outer segment, but why? This study in #zebrafish shows that the wavelength sensitivity of the expressed #opsin and the intensity of light exposure determine outer segment morphology @plosbiology.org 🧪 plos.io/4aKJi15
Researchers discovered a new photoreceptor!
A hybrid rod-like cone is found in some fish species that live at depths of up to 200 m allowing them to see in gloomy water.
Read the OPN story: https://bit.ly/40kKXW8
#vision #photoreceptor #technology 💡 ⚛️ 🧪
Left: This image visualizes the precise retinal mosaic formed by ultraviolet-sensitive cone (red) cells in zebrafish, highlighting the organized cellular landscape that underlies this research. Right: This image highlights the abundant cone population in the adult zebrafish retina, with UV-sensitive cones distributed throughout the tissue. The visualization, achieved using the Tg(sws1:GFP) transgene to label UV cone cell bodies. Creator: Jingjin Xu.
#Photoreceptor cells vary in the morphology of the light-absorbing outer segment, but why? This study in #zebrafish shows that the wavelength sensitivity of the expressed #opsin and the intensity of light exposure determine outer segment morphology @plosbiology.org 🧪 plos.io/4aKJi15
Left: This image visualizes the precise retinal mosaic formed by ultraviolet-sensitive cone (red) cells in zebrafish, highlighting the organized cellular landscape that underlies this research. Right: This image highlights the abundant cone population in the adult zebrafish retina, with UV-sensitive cones distributed throughout the tissue. The visualization, achieved using the Tg(sws1:GFP) transgene to label UV cone cell bodies. Creator: Jingjin Xu.
#Photoreceptor cells vary in the morphology of the light-absorbing outer segment, but why? This study in #zebrafish shows that the wavelength sensitivity of the expressed #opsin and the intensity of light exposure determine outer segment morphology @plosbiology.org 🧪 plos.io/4aKJi15
RESEARCH PAPER: DIO3 coordinates photoreceptor development timing and fate stability in human retinal organoids
By McNerney et al., and Robert Johnston, Jr.
➡️ https://genesdev.cshlp.org/content/40/1-2/70.full
Bob Johnston Christina McNerney Johns Hopkins University
#photoreceptor #hormone #neurons
Human CRX regulates #photoreceptor cell development via bidirectional transcriptional control in retinal #organoids, providing critical insights into the role of human CRX in retinal development and implications for retinal degenerative diseases. https://ow.ly/BRZr50XMwQz
ISSCR
Maarten was an Arabidopsis pioneer & during his PhD isolated first #phytohormone (GA,ABA) & #photoreceptor mutants.
www.arabidopsis.org/ais/1977/koo...
www.arabidopsis.org/ais/1978/koo...
link.springer.com/article/10.1...
link.springer.com/article/10.1...
onlinelibrary.wiley.com/doi/abs/10.1...
A major surprise was Nadja’s observation that early stages of the worm eye’s #photoreceptor cells expressed a ciliary #opsin gene known from #vertebrate visual photoreceptors. We hypothesized that this opsin might mediate an effect of light on proper development of worm eye photoreceptors… [4/7]
This review examines photoreceptor cell metabolism, interactions with retinal pigment epithelium, metabolic stress-induced pathologies, and future research directions in retinal health and disease.
#HM #photoreceptor #retina #metabolism
www.sciltp.com/journals/hm/...
Left: The active DNA methylation cycle. (i) 5mC is added by DNMTs. (ii) The TET enzymes oxidize 5mC to 5hmC. (iii) 5hmC is converted to 5fC and 5caC by the TET enzymes, followed by conversion back to cytosine by TDG and the base-excision repair pathway. (iv) Alternatively, APOBEC converts 5mC to thymine, causing DNA mismatch. Right: H&E staining of an allelic series of TET conditional P21 mutants.
TET enzymes remove #DNAmethylation markers; @ismaelhdeznunez.bsky.social @clark-lab-retina.bsky.social &co show that these enzymes are required for #photoreceptor cells to initiate the genetic program to become rods instead of cones, & for maturation of the #retina @plosbiology.org 🧪 plos.io/3UaVBfl
Left: The active DNA methylation cycle. (i) 5mC is added by DNMTs. (ii) The TET enzymes oxidize 5mC to 5hmC. (iii) 5hmC is converted to 5fC and 5caC by the TET enzymes, followed by conversion back to cytosine by TDG and the base-excision repair pathway. (iv) Alternatively, APOBEC converts 5mC to thymine, causing DNA mismatch. Right: H&E staining of an allelic series of TET conditional P21 mutants.
TET enzymes remove #DNAmethylation markers; @ismaelhdeznunez.bsky.social @clark-lab-retina.bsky.social &co show that these enzymes are required for #photoreceptor cells to initiate the genetic program to become rods instead of cones, & for maturation of the #retina @plosbiology.org 🧪 plos.io/3UaVBfl
Left: The active DNA methylation cycle. (i) 5mC is added by DNMTs. (ii) The TET enzymes oxidize 5mC to 5hmC. (iii) 5hmC is converted to 5fC and 5caC by the TET enzymes, followed by conversion back to cytosine by TDG and the base-excision repair pathway. (iv) Alternatively, APOBEC converts 5mC to thymine, causing DNA mismatch. Right: H&E staining of an allelic series of TET conditional P21 mutants.
TET enzymes remove #DNAmethylation markers; @ismaelhdeznunez.bsky.social @clark-lab-retina.bsky.social &co show that these enzymes are required for #photoreceptor cells to initiate the genetic program to become rods instead of cones, & for maturation of the #retina @plosbiology.org 🧪 plos.io/3UaVBfl
#FluorescenceFriday 🐥:3D projection of #GluSnFR expression in #chick #retina following #AAV transduction. Expression is concentrated in the #photoreceptor layer.
🟢 GluSnFR (glutamate sensor)
🔴 DAPI-stained nuclei
#Imaging #AAV #Retina #Biosensor #neuron #vision
(doi.org/10.3389/fphys.2025.1549585)
#CIBpapers
A team from @cib-csic.bsky.social discovered that deferiprone, used to eliminate excess iron in the body, protects retinal #photoreceptor cells from degeneration.
🔗https://f.mtr.cool/lsxdqioyig
The beautiful single cone #Photoreceptor types in the #retina of #chicken expressing #GFP via my #Intravitreal AAV injections.
For more insight, check out my recent publication (www.frontiersin.org/journals/phy...)
Great images for #FluorescenceFriday.
#birds #AAVs #injections #transduction
Here’s our final review for this semester prereview.org/reviews/1536...
#PreprintReview via
@prereview.bsky.social
@asapbio.bsky.social
@iubiology.bsky.social
Looking forward to discussion 🪰💡🩵!
#neuroscience
#drosophila
#photoreceptor
#redox
@flybase.bsky.social
@bdsc.bsky.social
A realistic look at rod synapses. Our latest Research News features work by Thoreson et al. (doi.org/10.1085/jgp....), who performed anatomically realistic simulations of rod #photoreceptor #synapses based on reconstructions from serial electron micrographs. rupress.org/jgp/article/...
MAGIK: Human cone #photoreceptor transplantation in an AIPL1 model of end-stage Leber congenital amaurosis drives retinal remodeling & function, with light-evoked head-tracking behavior at physiologically relevant light levels
ow.ly/cVnA50Vq3nq
@isscr.org
Orange is the new black...
Fukazawa et al. show how DUC1 #photoreceptor (which reversibly photoconverts between orange-absorbing dark-adapted state & far-red-absorbing photoproduct state) in the marine green alga P. provasolli is able to perceive orange light
doi.org/10.1093/pcp/...
#plantscience
#NewNProt for generation of #photoreceptor progenitors from #humanpluripotentstemcells under xeno-free and chemically defined conditions bit.ly/3F6Nqwd
The beautiful #Horizontalcell types in the #retina of #chicken
The distinction in the dendrites is amazingly clear, with each dendritic branch contacting a certain #photoreceptor type.
#Avian retinal #neurons are truly mesmerizing.
Great images for #FluorescenceFriday.
#birds #AAVs #injections
The beauty of #avianretina is ever expanding.
These magnificently colored dots called #oildroplets are located in the #photoreceptor #cones and intercept and filter the incoming #light.
They're found in #diurnal #reptiles and #birds and some other taxes, forming curious patterns.
🐔 #SciArt #chick
Professor Belinda Chang studies protein evolution, focusing on visual proteins like rhodopsin. One of her studies on evolution of rhodopsin showed that whales evolved swiftly to become deep divers #evolution #photoreceptor #rhodopsin 🧪 www.utoronto.ca/news/whales-...
