Unstructured transcription factor interactions enable emergent specificity How intrinsically disordered regions (IDRs) influence chromatin binding and nuclear organization of transcription factors (TFs) remains unclear. We employed proximity-assisted photoactivation (PAPA), ...

While #DNAbindingdomains & #IntrinsicallyDisorderedRegions individually do not show binding specificity, "ensembles of diverse, unstructured interactions" collectively enable emergent #TranscriptionFactor specificity ➡️ www.science.org/doi/10.1126/...
#generegulation #IDRs #TFspecificity #chromatin

RESEARCH PAPER: PHA-4/FoxA controls the function of pharyngeal and extrapharyngeal enteric neurons in C. elegans
By Walker et al., and Oliver Hobert
➡️ https://genesdev.cshlp.org/content/40/5-6/366.full

Columbia University HHMI
#transcriptionfactor #Celegans #neuron #gut

RESEARCH PAPER: Independent control of neurogenesis and dorsoventral patterning by NKX2-2
By Jang et al., and Hynek Wichterle
➡️ https://genesdev.cshlp.org/content/40/5-6/384.full

Columbia University
#transcriptionfactor #motorneuron #neurogenesis #spinalpatterning #Tinman

🆕 ADVANCE ONLINE 🆕

RESEARCH PAPER: Independent control of neurogenesis and dorsoventral patterning by NKX2-2
By Jang et al., and Hynek Wichterle
➡️ genesdev.cshlp.org/content/early/2026/01/12...

#transcriptionfactor #motorneuron #neurogenesis #spinalpatterning #Tinman

RESEARCH PAPER: B-lineage commitment is dependent on a reversible epigenetic switch
By Tingvall-Gustafsson et al., and Mikael Sigvardsson
➡️ https://genesdev.cshlp.org/content/40/3-4/233.full

Linköping University @lunduniversity.bsky.social
#hematopoiesis #Bcell #transcriptionfactor #epigenetics

🆕 ADVANCE ONLINE 🆕

RESEARCH PAPER: B-lineage commitment is dependent on a reversible epigenetic switch
By Tingvall-Gustafsson et al., and Mikael Sigvardsson
➡️ genesdev.cshlp.org/content/early/2025/11/20...


#hematopoiesis #Bcell #transcriptionfactor #epigenetics

Insufficient TRPM5 Mediates Lipotoxicity-induced Pancreatic β-cell Dysfunction

#TRPM5 expression decreases in #Lipotoxic #βcelldysfunction while overexpression reverses GSIS impairment & restores #TranscriptionFactor activity, providing a theoretical foundation for novel #Type2Diabetes therapies. #medsky
Read: link.springer.com/article/10.1...

New publication — NKX2-1 in T-cell leukemia

Happy that our work “NKX2-1 regulates cell survival, maturation, and DNA-damage response as cofactor of RUNX1 in T-cell leukemia” is published in Haematologica.

🔗 haematologica.org/haematologic...

#Leukemia #TALL #TranscriptionFactor #AcademicTwitter

🎄Our last issue for 2025 is out!
Cover: human trunk development model

🔬 #EmbryoModels #proteostasis #tRNA #ferroptosis #trogocytosis #mechanobiology #chromatin #TranscriptionFactor #epigenetics #ExtracellularVesicles #hematopoiesis #cancer #PhaseSeparation & more!
www.nature.com/ncb/volumes/...

OUTLOOK: MEF2C networks in heart tube development
By Hassan Abdulrazzak and Mark Mercola
➡️ https://genesdev.cshlp.org/content/39/23-24/1397.full

Learn more here:
➡️ genesdev.cshlp.org/content/39/23-24/1451.ab...

#transcriptionfactor #embryonicdevelopment #heartdevelopment #cardiactract

RESEARCH PAPER: MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis
By Muncie-Vasic et al. and Benoit Bruneau
➡️ genesdev.cshlp.org/content/39/23-24/1451.ab...

Jon Muncie-Vasic Benoit Bruneau

#transcriptionfactor #embryodevelopment #cardiactract

Protective microglia subtype offers potential new therapeutic pathway in Alzheimer’s disease – BioNews Central Lowering transcription factor PU.1 increases protective microglia with immunoregulatory receptors that suppress brain inflammation and support cognition in Alzheimer’s disease models.

Lowering #TranscriptionFactor PU.1 increases protective #microglia with #immunoregulatory receptors that suppress #BrainInflammation and support #cognition in #AlzheimersDisease models.
#PU1 #Neuroinflammation #ImmuneRegulation

Big pharma seduced by transcription factors again. What has changed? - Nature Biotechnology Long considered undruggable, transcription factors have finally become fair game for a clutch of innovative biotechs who are combining biological insights with innovative chemistry to bring into play ...

Are #TranscriptionFactors no longer "undruggable"? Recent innovations in small molecule chemistry, peptide design, #chemoproteomics, #structuralbiology make modulating #TranscriptionFactor activity possible ➡️
www.nature.com/articles/s41...

This new study shows that ATPase family AAA domain-containing protein 2 (ATAD2) promotes #Pyruvate dehydrogenase kinase 1 by synergising with E2F #TranscriptionFactor 1 in #Glioma, positioning ATAD2 as a novel #therapeutic target. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...

This review summarizes current knowledge and calls for deeper research into the role of T-box #TranscriptionFactor 4 (#TBX4) in #Human health and underscores its potential as a #Diagnostic and #therapeutic target. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...

RESEARCH PAPER: Opposing lineage specifiers induce a pro-tumor hybrid identity state in lung adenocarcinoma
By Fort et al.
➡️ https://tinyurl.com/gd352742

#cancer #gastrointestinal #lung #transcriptionfactor #tumorigenesis #RAS/MEK #signaling #lineage #plasticity #cancertherapy

Close up of beaver stepping into water. The Canadian Science Publishing logo sits in the top left corner and the Canadian Science Publishing blaze emblem sits in the bottom right.

Genome welcomes unlimited fee-free open access submissions from @crkn-rcdr.bsky.social authors and provides unlimited Read Access to all research. Publish with us 🍁▶️ buff.ly/oUyzd2x

🧬🔄 #genomics #transcriptionfactor #chromatin #nucleosome #regulatorynetwork #generegulation #epigenome

Mechanisms leading to paralog-specific binding profiles.

#TansleyReview: Mechanisms driving functional divergence of #TranscriptionFactor paralogs

Isabella J. Higgins, Sarah G. Choudury & Aman Y. Husbands 👇

📖 nph.onlinelibrary.wiley.com/doi/10.1111/...

Image credit: @gloglita.bsky.social‬ @lifescienceeditors.bsky.social‬ captured DynaTag in action: a pA-Tn5 probe (multicoloured) binds an antibody (white), which binds p53 DNA-binding domain (green) on DNA (blue) within 2 nucleosomes

🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)

🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.

The newly developed DynaTag by Robert and his lab @epistrucstab.bsky.social is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com‬ paper: www.nature.com/articles/s41...

Multiple mechanisms explain loss of anthocyanins from betalain‐pigmented Caryophyllales, including repeated wholesale loss of a key anthocyanidin synthesis enzyme In this study, we investigate the genetic mechanisms responsible for the loss of anthocyanins in betalain-pigmented Caryophyllales, considering our hypothesis of multiple transitions to betalain pig.....

Multiple mechanisms explain loss of anthocyanins from betalain-pigmented Caryophyllales, including repeated wholesale loss of a key anthocyanidin synthesis enzyme
doi.org/10.1111/nph....

#Anthocyanins #Flavonoids #Betalains #Caryophyllales #Evolution #Biosynthesis #TranscriptionFactor #Evolution

Demonstration of the role of RBM47 as a #transcriptionfactor that drives the up-regulation of LINC00862, a novel #lncRNA, which forms a complex with #CHD5, thereby enhancing RBM47 transcriptional activity and suppression of #HCC. #medsky
#OpenAccess:

Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression Zinc finger proteins (ZNFs) are the largest family of transcription factors, yet how they activate gene expression remains unclear. In this study, we identified Zincore, a protein complex consisting o...

Zincore: an unconventional coregulator complex that interacts with the DNA binding domain of #zincfinger transcription factors & stabilizes them on their genomic consensus motifs ➡️ www.science.org/doi/10.1126/... #generegulation #transcriptionfactor #transcription

Finding answers in surprising places. Disease causing variants found in the EYS promoter. #retinitispigmentosa #transcriptionfactor bit.ly/450IlQR

A fungal transcription factor converts a beneficial root endophyte into an anthracnose leaf pathogen Endophytic fungi colonize healthy plant tissues without disease. Ujimatsu et al. reveal that the fungal transcription factor CtBOT6 triggers the virulence of a root-associated beneficial endophyte by ...

A fungal transcription factor converts a beneficial root endophyte into an anthracnose leaf pathogen

#endophyticfungi
#fungallifestyles
#transcriptionfactor
#virulence
#Arabidopsis
#Colletotrichum
#mutualist-pathogencontinuum
#abscisicacid
#necrotrophy

www.cell.com/current-biol...

#targetsearch #pioneering #transcriptionfactor #chromatin #singlemoleculeimaging #IDR #biophysics #Sox2 #TF-DNAinteractions

Exportin-1 functions as an adaptor for transcription factor-mediated docking of chromatin at the nuclear pore complex Many genes physically interact with the nuclear pore complex (NPC), which requires transcription factors (TFs). Ge et al. show that the exportin Crm1 binds TFs and nuclear pore proteins to dock chroma...

Cool! New role for #Exportin1 #Crm1 #Xpo1
#Adaptor #NuclearPore #NPC #TranscriptionFactor

Exportin-1 functions as an adaptor for transcription factor-mediated docking of chromatin at the nuclear pore complex: Molecular Cell www.cell.com/molecular-ce...

A comprehensive review of transcription factor-mediated regulation of secondary metabolites in plants under environmental stress - Stress Biology Plants encounter a wide range of biotic and abiotic environmental stresses throughout their lifespan. To adapt and survive, they have evolved complex defense mechanisms that involve the production of ...

A comprehensive review of transcription factor-mediated regulation of secondary metabolites in plants under environmental stress
Karim Rabeh, Mohamed Hnini, Malika Oubohssaine

link.springer.com/article/10.1...

#SecondaryMetabolite #TranscriptionFactor #AbioticStress #BioticStress

Intrinsically disordered regions as facilitators of the transcription factor target search - Nature Reviews Genetics Intrinsically disordered domains (IDRs) are increasingly appreciated as important components of protein function. This Perspective discusses the emerging evidence for IDRs from transcription factors a...

Interesting piece on the role of intrinsically disordered regions in #transcriptionfactor specificity, target search etc. ➡️ www.nature.com/articles/s41... #generegulation

BLUE WHALE Blue whales It is largest animal on the planet. It seems to be largest animal to live on the Earth.

Blue Whale
#science
#nationalgeographic
#wwf
#cancer
#whales
#bluewhale
#promoter
#transcriptionfactor
#gene
#breastcancer
#krill
#mammal

www.linkedin.com/pulse/blue-w...