Multiomic single-cell perturbation screens reveal critical lncRNA regulators of senescence - Nature Aging To dissect lncRNA functions in aging, here the authors perform a CRISPRi-based single-nucleus multiomics screen systematically perturbing 32 aging- and senescence-associated lncRNAs and measuring matc...

Epigenetics Update - Multiomic single-cell perturbation screens reveal critical lncRNA regulators of senescence go.nature.com/47Aev6m

Shouxuan Zhu / Sunyang Ying and Jing-Dong J. Han from @pku1898.bsky.social in Nature Aging

#Epigenetics #Multiomics #SingleCell #LncRNAs
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epigenometech.com

Epigenetics Update - An EGFR co-amplified lncRNA HELDR promotes glioblastoma malignancy through KAT7-driven gene programs go.nature.com/3Pxyuwl

Xiaozhou Yu and Bo Hu/Shi-Yuan Cheng (Northwestern University) in Nat Cell Biol

#Epigenetics #KAT7A #Glioblastoma #lncRNAs
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epigenometech.com

Epigenetics Update - The XSER1 lncRNA acts as an enhancer RNA and confers resistance to pathogens by promoting chromatin loop formation in rice bit.ly/3NNJlBK

#Epigenetics #LncRNAs #Chromatin #EnhancerLoop #Rice #Plants
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High-resolution insights without cell sorting; epigenometech.com

This review summarizes how #lncRNAs regulate the #AMPK signaling pathway by interacting with DNA, RNA, and proteins, shaping cellular energy homeostasis, metabolism, #aging processes, and the development of #AgeRelatedDiseases.

#OpenAccess: doi.org/10.1016/j.ge...

Scientists highlight how #lncRNAs regulate #NKcell development, activation, #cytotoxicity, and #TumorInfiltration via transcriptional control, #miRNA sponging, metabolism, ubiquitination, and epigenetics, highlighting their therapeutic potential.

#OpenAccess: doi.org/10.1016/j.ge...

Association of tumour-associated macrophage states with non-conserved lncrnas in lung cancer - Genes & Immunity Genes & Immunity - Association of tumour-associated macrophage states with non-conserved lncrnas in lung cancer

🌅 #Research #Alert
Association of #tumour-associated #macrophage states with non-conserved #lncrnas in #lung #cancer
@leuccilrcb.bsky.social

@springernature.com #Genes & #Immunity
www.nature.com/articles/s41...

Recent review reveals how regulatory #Pseudogene-derived #lncRNAs shape #Cancer #DrugResistance and outlines therapeutic opportunities to overcome treatment failure. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Cinque, Verheyden, Adnane et al. @leuccilrcb.bsky.social reveal the contribution of #lncRNAs to the generation of cancer-specific #ribosomes and identify an RNA-based strategy to overcome resistance to immune checkpoint blockade. rupress.org/jem/article/...

#Melanoma

A new review explores #lncRNAs in #HBV and their dysregulation in #HCC, highlighting their roles as diagnostic and therapeutic #Biomarkers with dual #Tumor-promoting and -suppressive effects. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

This review highlights the role of #Exosome/circulating #lncRNAs in #KidneyDiseases, exploring the #DiseaseMechanisms, their potential as #Biomarkers & #therapeutic agents, & also offers new insights into lncRNA-based treatments. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

This review shows that #lncRNAs govern #NKcell biology in #Pathological conditions, and highlights that their regulatory role in the #TumorMicroenvironment positions them as novel #therapeutic targets in NK cell #Dysfunction. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...

This review shows that #lncRNAs govern #NKcell biology in #Pathological conditions, and highlights that their regulatory role in the #TumorMicroenvironment positions them as novel #therapeutic targets in NK cell #Dysfunction. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...

This review explores the roles of pseudogene-derived #lncRNAs in modulating #CancerStemCells across multiple #Cancers and their #Clinical potential as #Biomarkers, #Diagnostics and #therapeutic targets. @tumscvdri.bsky.social #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...

This review focuses on the interaction between #lncRNAs and #NKCell biology, highlighting its potential as a therapeutic target in diseases involving NK cell dysfunction. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...

Excited to share our new preprint: Local Non-Coding Regulatory Elements in the Muscular Dystrophies 🚀
We review how #lncRNAs, #miRNAs, and epigenetic regulators shape disease mechanisms in #DMD, #FSHD, #LGMD & more. www.preprints.org/manuscript/2... #preprints via @Preprints_org

Now is the turn of @stacedw.bsky.social telling us about a #lncRNA as a therapeutic for ER+ breast cancer. Cannot share more details, but I can say seeing the promise of #lncRNAs starting to bear fruit is very exciting!

#ARNASydney2025 #RNASky

Now available: UltraMarathonRT® cDNA Synthesis & Amplification Kit!

Elevate short-read #RNAseq with unmatched processivity: detect rare isoforms & #lncRNAs, quantify long transcripts, and integrate seamlessly with Illumina®-style workflows.

Press release🔗in the comments.

#RNASky #transcriptomics

Human long non-coding RNAs acquired from bacteria via horizontal gene transfer promote gallbladder cancer - Molecular Biology Reports Background Gallbladder cancer, the most common malignancy of the bile duct, has a poorly understood etiopathogenesis. Non-coding RNAs are implicated in various cancers, but their role in gallbladder c...

Exited to share that our new study reveals #bacterial_lncRNAs, acquired by humans via #horizontal_gene_transfer, promote #gallbladder_cancer progression. This breakthrough can lead to better diagnosis and treatment options for this aggressive disease🧬🦠

✅ Doi: doi.org/10.1007/s110...

#lncRNAs #GBC

📑 New Review to save for later!

Liver-specific lncRNAs associated with liver cancers

➡️ buff.ly/qRP09wo

#lncRNAs #HCC #Biomarkers #LiverCancer #NoncodingRNAs

Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer

This review describes the various #GenomicAlterations of #lncRNAs in cancer, with a special focus on #GeneFusions in lncRNAs and their implications in #cancer. It also discusses the therapeutic opportunities and challenges they present. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Nuclear and cytoplasmic USP30-AS1 coordinately regulate breast cancer progression through HnRNPF/p21 and EZH2/c-Myc/p21 axes

Researchers provide mechanistic insights into the #oncogenic role of USP30-AS1 in #BreastCancer progression via the HnRNPF/p21 and EZH2/c-Myc/p21 axis, highlighting it as a potential therapeutic target in breast cancer treatment. #lncRNAs #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Urinary exosomal lnc-TAF12–2:1 promotes bladder cancer progression through the miR-7847–3p/ASB12 regulatory axis

LncRNAs and bladder cancer. An intriguing read!

Exosomal lnc-TAF12–2:1 acts as a miR-7847–3p sponge, activating the miR-7847–3p/ASB12 regulatory axis and promoting #BladderCancer #tumorigenesis. #exosomes #lncRNAs #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Urinary exosomal lnc-TAF12–2:1 promotes bladder cancer progression through the miR-7847–3p/ASB12 regulatory axis

LncRNAs and bladder cancer. An intriguing read!

Exosomal lnc-TAF12–2:1 acts as a miR-7847–3p sponge, activating the miR-7847–3p/ASB12 regulatory axis and promoting #BladderCancer #tumorigenesis. #exosomes #lncRNAs #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Finally made it to #AACR2025! Just in time for my postdocs poster. Super proud of Dr. Richa Mishra and her work on #lncRNAs and #breastcancer. Stop by and learn more☺️ @theaacr.bsky.social @sitemancenter.bsky.social @washumedicine.bsky.social #SilvaFisherlab

Amazing much needed vacation with family and now heading to Houston for the Cell and Experimental Biology meeting to present on #lncRNAs and #myeloma! @washumedicine.bsky.social @sitemancenter.bsky.social #SilvaFisherlab

LncRNAs are involved in regulating ageing and age-related disease through the adenosine monophosphate-activated protein kinase signalling pathway

This review describes the role of the AMPK signaling pathway in various biological processes and provides insights into how various #lncRNAs regulate this pathway in the context of #ageing and age-related disorders. #Autophagy #medsky

#OpenAccess: www.sciencedirect.co...

And don't forget to follow us if you share our interest in #telomeres, #lncRNAs, #cancer, #aging, and #genomestability!

I travelled to Würzburg the last couple of days for the Joint Parasitology Spring Meeting from the DGP, BSP and SSTMP. I had the chance to present my project about the role of #lncRNAs in #Plasmodium #parasites. I met amazing researchers and I also got to meet old friends from my time at BNITM.

The role of lncRNAs in AKI and CKD: Molecular mechanisms, biomarkers, and potential therapeutic targets

This review summarizes the latest knowledge on the roles of #exosome #lncRNAs and circulating lncRNAs in the pathogenesis, biomarker discovery, & treatment of different #kidneydiseases, providing an overview of novel regulatory approaches and lncRNA delivery systems. #medsky

www.sciencedirect.co...

👏 A new study by @jamesaoo7.bsky.social and colleagues published in @naturecomms.bsky.social demonstrates that trans-acting long non-coding RNAs (lncRNAs) direct the SWI/SNF complex to cell type-specific enhancers. #chromatinremodeling #lncRNAs Read more here: cpi-online.de/paperofthemo...