Differential Expression of ATP6V1D and Its Diagnostic Potential in IgA Nephropathy

This study reveals significant downregulation of ATP6V1D in #IgAN compared with healthy controls & MN groups, with urinary ATP6V1D correlating negatively with #GDIgA1, showing promise as a #Biomarker for distinguishing IgAN from MN & MCD. #medsky

To read: doi.org/10.1007/s115...

Konjac Oligosaccharide Alleviates Constipation in Mice via 5-HT4R/cAMP/PKA/p-CREB Pathway Activation

This study indicates that #Konjac #Oligosaccharide exerts potent anti constipation effects via activation of the #5HT4R/cAMP/PKA/p CREB pathway, supporting its role as a natural #therapeutic strategy for functional #Constipation. #medsky
To read: doi.org/10.1007/s115...

This study provides #MedicalStaff with a solid foundation for selecting the most appropriate tools, thereby ensuring effective #NutritionalManagement and improved #PatientOutcomes. #medsky #Oncology #CancerResearch #ClinicalPractice #Nutrition
Read: link.springer.com/article/10.1...

The Protective Effects of Quercetin on Ferritinophagy in Alcoholic-Induced Liver Iron Overload

This study finds that #Quercetin protects against alcohol induced #LiverDamage by maintaining ferritinophagy & #Lysosome function via the #FOXO1-#TFEB-NCOA4 pathway, offering a promising #therapeutic avenue for secondary #IronOverload. #medsky
To read: doi.org/10.1007/s115...

A Real-World Pharmacological Assessment of Tenofovir Amibufenamide and Tenofovir Alafenamide in 48-Week Chronic Hepatitis B Treatment: Efficacy, Safety, and Cost-Effectiveness

This study highlights that #Tenofovir amibufenamide provides superior #Antiviral efficacy compared with TAF and underscores that strategies to improve affordability are required to ensure broader adoption of this promising therapy. #medsky
To read: doi.org/10.1007/s115...

Collagen-Coated 3D-TechTra Scaffold Integrated with Human Umbilical Cord Mesenchymal Stem Cells Enhances Tracheal Tissue Regeneration and Reduces Stenosis in Rabbit Models

This study demonstrates the synergistic potential of TPU/PLA scaffolds, collagen coatings & hUC MSCs, offering valuable evidence for advancing #Tracheal #TissueEngineering & supporting the development of future #Regenerativetherapies. #medsky
Read: doi.org/10.1007/s115...

Integrating CT Radiomics and Clinical Information to Predict Prognosis of Advanced NSCLC Patients Receiving Chemoimmunotherapy

This study introduces a novel #Radiomic #ClinicalModel for predicting progression free survival in advanced #NSCLC patients receiving first line #Chemoimmunotherapy and supports the integration of #Radiomics into #PrecisionOncology. #medsky
To read: doi.org/10.1007/s115...

Remimazolam-Remifentanil versus Propofol-Remifentanil for Spontaneous Ventilation During Fiberoptic Bronchoscopy: A Randomized Controlled Trial

This study finds that #Remimazolam -#Remifentanil provides effective #Sedation for #Fiberoptic #Bronchoscopy, compared with #Propofol - remifentanil, promising an alternative for maintaining spontaneous ventilation in #clinical settings. #medsky

Read: doi.org/10.1007/s115...

Association of MiR-29b/BRD4 with Airway Dysbiosis in Chronic Obstructive Pulmonary Disease after Smoking Cessation

This study shows that #AirwayInflammation in #COPD patients after #SmokingCessation is linked to airway #dysbiosis, with miR 29b/#BRD4 involvement, pointing to new molecular targets for #PrecisionMedicine.

To read: doi.org/10.1007/s115...

#Microbiome #Dysbiosis #medsky

Therapeutic Effects of Qifangfeixian Granules on Pulmonary Fibrosis in Patients with Interstitial Lung Disease

This study demonstrates that Qifangfeixian granules improve #PulmonaryFibrosis in #Bleomycin induced mice & enhance #PulmonaryFunction in #ILD patients, highlighting their #therapeutic potential across both experimental & #clinical practice. #medsky
To read: doi.org/10.1007/s115...

Global, Regional, and National Burden of Pulmonary Arterial Hypertension from 1990 to 2021 and Projections to 2040: A Systematic Analysis of Incidence, Mortality, and Disability-Adjusted Life Years

This study shows that #PAH burden is rising in #AgingPopulations & high‑middle SDI regions, while low‑SDI areas face underdiagnosis & disparities, underscoring the need for targeted interventions to reduce its global impact. #medsky #Cardiopulmonary

Read: doi.org/10.1007/s115...

Targeting miR-144-5p/ACSM1 Axis Alleviates Doxorubicin-Induced Heart Failure by Inhibiting Lipid Peroxidation

This study shows that inhibiting miR 144 5p alleviates #Doxorubicin induced #HeartFailure by targeting ACSM1 and reducing #LipidPeroxidation, suggesting the miR 144 5p/ACSM1 axis as a novel #therapeutic target. #medsky #HeartFailure #Cardiotoxicity

Full article here: doi.org/10.1007/s115...

Novel Prognostic Scoring Systems for Severe CRS after Anti-CD19 CAR-T-Cells in Acute B-Lymphoblastic Leukemia

This study developed a #PrognosticScoringSystem for severe #CRS in Chinese B ALL patients receiving #AntiCD19 #CARTCellTherapy, integrating #clinical and laboratory parameters to support early identification and management. #medsky

#OpenAccess: doi.org/10.1007/s115...

CD44v6 CAR-T Cells Target DNMT3A-Mutant AML: Synergistic Enhancement by Decitabine

This study highlights #CD44v6 as a promising #CARTCellTherapy target in #AML patients with #DNMT3A mutations, suggesting a novel strategy that combines #Epigenetic modulation with CAR T therapy to advance precision treatment in AML. #medsky
Read: doi.org/10.1007/s115...

Multifunctional Roles and Therapeutic Prospects of C1q/TNF-Related Protein 3 (CTRP3) in Human Diseases

This review summarizes the role of CTRP3 in various disorders, explores its mechanistic pathways, and highlights #therapeutic implications, positioning CTRP3 as a promising target for future #clinical strategies. #medsky #Pathophysiology #MetabolicRegulation

To read: doi.org/10.1007/s115...

Artificial Intelligence in Traditional Chinese Medicine: Multimodal Fusion and Machine Learning for Enhanced Diagnosis and Treatment Efficacy

This study examines the integration of #AI into #TCM, underscoring the importance of combining technological innovation with traditional medical knowledge to advance precision, accessibility & global recognition of TCM. #medsky

To read: doi.org/10.1007/s115...

Current Status and Advances in Anti-Androgen Therapy for Triple-Negative Breast Cancer

This article systematically reviews #Androgen #TargetedTherapy for #TripleNegativeBreastCancer, incorporating recent advances and charting future directions in both research and #clinical practice. #medsky

Full article here: doi.org/10.1007/s115...

mRNA Vaccines in Cancer Immunotherapy: Recent Advances, Clinical Translation, and Future Perspectives

This comprehensive review examines the mechanisms and #clinical applications of #mRNACancerVaccines, highlighting their potential to revolutionize #Oncology. #medsky

Full article here: doi.org/10.1007/s115...

#LifeSciences #AcademicPublishing #OpenAccess #PeerReviewed

Regulation of Alternative Splicing by PARP1 in HTR-8/Svneo Cells: Implications for Placental Development and Spontaneous Abortion

The findings of this study confirm the role of #PARP1 in regulating #Cytotrophoblast function, advancing our understanding of #PregnancyLoss and identifying potential #therapeutic targets. #medsky

Full article here: doi.org/10.1007/s115...

Causal Link between Gut Microbiota and Infertility: A Two-sample Bidirectional Mendelian Randomization Study

This MR analysis reveals a bidirectional causal link between #GutMicrobiota & #Infertility, offering new perspectives on #Microbial mechanisms underlying #ReproductiveHealth & informing future #diagnostic & #therapeuticstrategies. #medsky

To read: doi.org/10.1007/s115...

World Health Day 2026

On #WorldHealthDay, Current Medical Science highlights advances in translational & #clinicalresearch addressing global health challenges, and invites scholars to explore its publications driving innovation in disease prevention, diagnosis, & therapy.
Visit: link.springer.com/journal/11596

Genome-integrated Human Papilloma Viruses Testing: A Complement to Colposcopy-guided Biopsy for Cervical Cancer Screening

This study highlights #HPV integration testing as a powerful adjunct to # Colposcopy-guided #Biopsy and #Cytology, offering a comprehensive diagnostic approach to identify high-grade #CervicalLesions and to guide better patient care. #medsky #CancerPrevention

To read: doi.org/10.1007/s115...

Effects of Exosomes from Menstrual Blood-derived Stem Cells and Ginger on Endometriotic Stem Cells

This study demonstrates that natural #Exosomes can reprogram #GeneExpression in #Endometriotic #StemCells toward healthier states, with plant derived exosomes showing cost effective promise as #NaturalTherapies for #Endometriosis. #medsky

To read: doi.org/10.1007/s115...

TREM2-mediated Macrophage Glycolysis Promotes Skin Wound Angiogenesis via the Akt/mTOR/HIF-1α Signaling Axis

This study finds that #TREM2⁺ #Macrophages drive # WoundRepair by linking #Glycolysis to #Angiogenesis via Akt/#mTOR/#HIF1α pathway, revealing #therapeutic targets for #TissueRegeneration. #medsky

Full article here: doi.org/10.1007/s115...
#WoundHealing #TherapeuticTargets #DrugDiscovery

FKBP5 Regulates the Osteogenesis of Human Adipose-derived Mesenchymal Stem Cells

This research shows that #FKBP5 promotes ASC #OsteogenicDifferentiation, highlighting the potential of FKBP5 targeted therapies for #BoneDisorders & proposing a controllable strategy for ASC based #Transplantation in #BoneDefect repair. #medsky
Read: doi.org/10.1007/s115...

Kaempferol Improved Rheumatoid Arthritis by Regulating the Immune Imbalance of Treg/Th17

This study shows Kae alleviates #Arthritis in mice by balancing #Treg/#Th17 via the #miR34a/#Foxp3 axis, highlighting #therapeutic potential for #RA and #Immune #Homeostasis. #medsky

Full article here: doi.org/10.1007/s115...

#TargetDiscovery #TherapeuticTargets #DrugDevelopment

Contribution of ECT2 to Tubulointerstitial Fibrosis in the Progression of Chronic Kidney Disease

This research utilizes diverse bioinformatic strategies and identifies ECT2, CASP7, #COL4A1, and #CCNB1 as #CKD genes, with ECT2 driving #fibrosis and progression, revealing novel #MolecularTargets for #KidneyResearch. @2024_HUST #medsky

To read: doi.org/10.1007/s115...

Jianpi Huoxue Decoction Ameliorates Alcohol-associated Liver Disease by Improving Intestinal Barrier Function in Rats

This study demonstrates that Jianpi Huoxue Decoction protects against #ALD by reducing LPS, strengthening #Intestinal barriers, and modulating #GutLiverAxis health. #medsky

To read: doi.org/10.1007/s115...

#Hepatology #LiverDisease #IntestinalBarrier #HerbalMedicine #AcademicBluesky

LncRNA H19 Activates the RAS-MAPK Signaling Pathway via miR-140-5p/SOS1 Axis in Malignant Liver Tumors

This study confirms that H19 activates the Ras–#MAPK pathway via the miR 140 5p/#SOS1 axis, driving #LiverTumor proliferation and invasion, and provides a theoretical basis for the #clinical application of H19 in #Liver #CancerTherapy. #medsky

Read here: doi.org/10.1007/s115...

Cell Cycle-Related LncRNA-Based Prognostic Model for Hepatocellular Carcinoma: Integrating Immune Microenvironment and Treatment Response

This study introduces a risk score model that improves #prognostication in #HepatocellularCarcinoma, identifies high risk patients, and guides the development of novel #Immunotherapy strategies. #medsky

To read: doi.org/10.1007/s115...