Men of Bury – Book your AAA screening.

AAA often has no symptoms, so screening is the only way to know. A quick, painless, free test could save your life.
☎️ Men aged 64+: Call 0161 291 5716 #abdominalaorticaneurysm #Bury

RRAS2 #AbdominalAorticAneurysm

Ang II▶️⏬MEG3▶️⏬RRAS2 in aortic Smooth Muscle Cell

CLIP-seq RNA-binding protein of MEG3
+ MEG3 IP-MS
+ CatRAPID predicted RRAS2 interactome▶️ ELAVL1▶️
⏫RRAS2 mRNA stability

SMC Rras2 KO🐭 +AngII or elastase
⏫AAA

#NatComm 2025
www.nature.com/articles/s41...

👨‍⚕️ Men of Bury — get your AAA screening. AAA often has no symptoms, so the only way to know is to get checked. It’s free, quick, painless and could save your life. #abdominalaorticaneurysm #Bury

Using #Multiomics and #ChIPseq, this #STTT study identified #MAPK14 as a central driver of #AbdominalAorticAneurysm that promotes #VSMC degeneration, suggesting the VSMC-MAPK14 axis as a potent #TherapeuticTarget to mitigate #AAA. #Medsky

#OpenAccess: doi.org/10.1038/s413...

Integrated single-nucleus #Multiomics, SRF #ChIPseq and experimental validation identified MAPK14 as a master regulator of transcriptional remodeling in #VSMCs, providing insights into how its inhibition protects against #AbdominalAorticAneurysm.

#OpenAccess: doi.org/10.1038/s413...

Identification of BTC and KLF15 in Vascular Smooth Muscle Cells as Key Biomarkers for Abdominal Aortic Aneurysm via Machine Learning and In Vitro Experiments Identifies BTC & KLF15 in vascular smooth muscle cells as AAA biomarkers via machine learning and in vitro validation, advancing diagnosis/therapy

Identification of #BTC and #KLF15 in #Vascular Smooth Muscle Cells as Key Biomarkers for #AbdominalAorticAneurysm via Machine Learning and In Vitro Experiments.

#OpenAccess: tinyurl.com/2a2jdovx

#AbdominalAorticAneurysm

Global p27 KO🐭 + topical elastase + oral BAPN➡️
⏫Abdominal aortic diameter
⏫SMC apoptosis
⏬SMC content
⏫Mφ infiltr (M1 polarized)

Any senescence?🧐

#JVascRes 2025
karger.com/jvr/article/...

#Colchicine alleviates #AbdominalAorticAneurysm
ApoE−/− mice +ANGII

Effects on Macrophage (down NLRP3 IL-1β TNFα MCP1) & #SmoothMuscleCell (up LOX TIMP1/2)
Unaltered aortic MMP2/9

Yuji Narita lab #CircJ 2025
www.jstage.jst.go.jp/article/circ...

Dr. Arya Receives NIH Funding to Research AAA in Women Dr. Shipra Arya has received more than $1 million in funding to study abdominal aortic aneurysms (AAA) in women from the National Institutes of Health (NIH).

Congratulations to Dr. Shipra Arya on receiving funding for the WARRIORS trial! Who else is ready to revolutionize AAA care for women?

surgery.stanford.edu/news2/Arya-W...

#womensHealth @VascularSVS #AbdominalAorticAneurysm

Multi-Omics Exploration of Risk Factors and Pathways Linking Respiratory Conditions and Abdominal Aortic Aneurysm Editorial highlights a multi-omics approach to uncover genetic and molecular mechanisms in chronic obstructive pulmonary disease and abdominal aortic aneurysm.

An editorial on a #Multiomics approach that provides a comprehensive understanding of the molecular mechanisms underlying #COPD and #AbdominalAorticAneurysm (AAA), highlighting the importance of routine AAA screening in COPD patients.

#OpenAccess: cvia-journal.org/multiomics-c...

Molecular mechanisms underlying COPD and AAA: A multi-omics approach A multi-omics approach for comprehensive understanding of the genetic and molecular mechanisms underlying COPD and Abdominal Aortic Aneurysm

This study used a #Multiomics approach to provide a comprehensive understanding of the #genetic and molecular mechanisms underlying #COPD and #AbdominalAorticAneurysm (AAA), underscoring the importance of COPD as a potential risk factor for AAA.

#OpenAccess: cvia-journal.org/molecular-re...

She came in with cold feet and stomach pain. What doctors found next could’ve killed her in minutes.

Subscribe to read more on www.pouringpotions.com

#AbdominalAorticAneurysm #AAA #MedicalEmergency #DoctorExplains #SilentKiller #ColdFeet #HealthAwareness #EmergencyMedicine

#PCSK9 #AbdominalAorticAneurysm

Global PCSK9 KO does Not modify serum lipids in ApoE SA/SA🐭+#WesternDiet!😨
But
⏫survival
⏬AAA
↔️aortic #SmoothMuscleCell content
⏬Mφ infiltr & inflammatory cytokines & MMP9

#ATVB 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...

#AbdominalAorticAneurysm (AAA) can be prevented by knowing the risk factors and getting screened. Your doctor can confirm the presence of an AAA with an abdominal ultrasound, abdominal and pelvic CT, or angiography. Learn more at tinyurl.com/2w4bywab
#MensHealthMonth #RadiologyInfo #Radsky

#Proteome & #Acetylome of mouse #AbdominalAorticAneurysm #AAA
8-wk Apoe-/-♂️🐭+ANGII

4581 (1184 differential) acetylated sites
1790 acetylated proteins

⏫Inflammation Immunity Complement #NeutrophilExtracellularTrap
⏬#BranchedChainAminoAcid catabolism

bioRxiv 2025
www.biorxiv.org/content/10.1...

My AAA Stent Graft and I Have Been Together Now, For Nearly 15 Years, and It Ain't Been a Day Too Long! Just reminiscing about my old stent, a Cook Zenith, that has kepts me on on the Ironman course for nearly 15 years.

-kev #abdominalaorticaneurysm

athletewithstent.com/aaa-stent-gr...

𝗨𝗻𝗱𝗲𝗿𝘀𝘁𝗮𝗻𝗱𝗶𝗻𝗴 𝗔𝗯𝗱𝗼𝗺𝗶𝗻𝗮𝗹 𝗔𝗼𝗿𝘁𝗶𝗰 𝗔𝗻𝗲𝘂𝗿𝘆𝘀𝗺 (𝗔𝗔𝗔): 𝗖𝗮𝘂𝘀𝗲𝘀, 𝗦𝘆𝗺𝗽𝘁𝗼𝗺𝘀, 𝗮𝗻𝗱 𝗧𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁
#post12
#AbdominalAorticAneurysm #AAA #VascularHealth #AskVikashMishra #HeartHealth #MedicareScreening #HealthAwareness #VikaasLLC

#MachineLearning ➡️ "ETS1 (enriched in #EndothelialCell T/B/NK cells) & ITPR3 as potential diagnostic genes for" #AbdominalAorticAneurysm

Trained
1⃣ GSE57691 #Oncotarget 2015
2⃣ CellAge
Validated
1⃣ #JAHA 2017 GSE98278
2⃣ #CSBJ 2023 GSE183464

#JCMM 2025
onlinelibrary.wiley.com/doi/10.1111/...

#Sirt6 #Senescence #AbdominalAorticAneurysm

Human mouse AAA IHC
⏫SMC senescence
⏬Sirt6

Sirt6 transgene in Apoe-/-🐭 +Angiotensin II➡️
⏬p21 (not p16)-mediated Aortic senescence
⏬Inflammation
⏬Adventitial #Angiogenesis

#Atherosclerosis 2024
www.atherosclerosis-journal.com/article/S002...

#SpatialTranscriptomics #GeoMx @brukerspatial
Human #AbdominalAorticAneurysm
3x Normal
3x CRP-hi AAA
3x CRP-lo AAA

#SmoothMuscleCell NFκB & JNK signals +corr. CRP level

To explore more in raw data?▶️PRJNA1146589 (SRA) ▶️ not found now😅

#FrontImmunol 2024
www.frontiersin.org/journals/imm...

#SpatialTranscriptomics #Visium @10xGenomics #AbdominalAorticAneurysm

THBS1/Thrombospodin-1 KO in Myeloid cell, not #EndothelialCell, ⬇️ #AorticAneurysm but⬆️ #AorticRupture in 🐭AAA AngII+Apoe KO

Likely compromised TGFb-ECM-stabilizing SMCs & fibroblasts

bioRxiv 2024
www.biorxiv.org/content/10.1...

Recombinant Endosialin (aka CD248/TEM1) i.p alleviates🐭 #AbdominalAorticAneurysm (CaCl2 or ANG II)

In👤aortic #SmoothMuscleCell Fibroblast, rEndosialin⏫TGFβ1/SMAD2 & Collagen deposition

Endosialin⏫in AAA, enriched in SMC/Fibroblast/Monocyte

#IntJBiolSci 2024
www.ijbs.com/v20p3691.htm

#ArteryOnAChip

Dual-channel flow
#EndothelialCell (1 Pa) + #SmoothMusclecell (0.0002 Pa)

Bulk RNAseq of EC-/+flow SMC▶️
Novel vascular regulatory genes in SMCs
CRYAB INHBA LRG1 ▶️
Validated in👤🐷🐭#Atherosclerosis #AbdominalAorticAneurysm

#AdvHealthcMater 2023
onlinelibrary.wiley.com/doi/10.1002/...

Disruption of PCSK9 Suppresses Inflammation and Attenuates Abdominal Aortic Aneurysm Formation | Arteriosclerosis, Thrombosis, and Vascular Biology BACKGROUND: Abdominal aortic aneurysm (AAA) is a chronic vascular inflammatory disease without effective medications. PCSK9 (proprotein convertase subtilisin/kexin 9), a serine protease from the propr...

PCSK9 global KO or siRNA PCSK9 ameliorated #AbdominalAorticAneurysm in hyperlipidemic hypertensive Apoe SA/SA🐭

A PCSK9-Sirt1 axis

PCSK9 detected in👤🐭aortic macrophages

Intravital imaging of femoral vein➡️leukocyte adhesion

#ATVB 2024 @ahascience.bsky.social
www.ahajournals.org/doi/10.1161/...

GWAMA Genome-wide association meta-analysis #AbdominalAorticAneurysm
14 cohorts
39k case + 1M ctrl
121 risk loci (97 new!)

Lipid & Non-Lipid genes; BOTH LDL-C & non-HDL-C

#PCSK9 KO🐭are resistant to elastase-induced #AAA

#AortaEd
#NatureGenet 2023
www.nature.com/articles/s41...

#SmoothMuscleCell NRF2 KO🐭are susceptible to Angiotensin II-induced #AbdominalAorticAneurysm

NRF2-miR-145 cascade

scRNAseq👤AAA▶️7 SMC clusters
Contractile 1/2
Fibroblast-like
Macrophage-like
Stem cell-like
T cell-like
Plasma cell-like

#FASEBJ 2024
faseb.onlinelibrary.wiley.com/doi/10.1096/...

#ERStress #AbdominalAorticAneurysm

Targeted delivery of PERK inhibitor to 🐭#AAA using biomimetic nanoclusters
PAMAM-PLGA nanoparticles coated with platelet membrane
i.v. >100-fold enriched in aortic lesions vs liver/GI/kidney/spleen🤠

#BioactiveMat 2023
www.sciencedirect.com/science/arti...

#LncRNA #CARMN #SmoothMuscleCell #AbdominalAorticAneurysm

CARMN⏬in🐭👤#AAA
CARMN transcription⏫by NRF2

🐭AAA elastase
⏫by AAV9-shCARMN
⏬ by AAV9-CARMN
CARMN⏫SRF➡️SMC contractile phenotype

Cell Mol Life Sci 2024
link.springer.com/article/10.1...

Female-Specific Considerations in Aortic Health & Disease
#AortaEd #AortaIsAnOrgan

#AorticAging
#ThoracicAorticDisease
#AbdominalAorticAneurysm

Hypertensive disorders of Pregnancy

Must-read👍

#CJCOpen 2024
www.sciencedirect.com/science/arti...