Researchers reveal m6A epigenetic modification controls arbovirus infection and transmission between vertebrates and mosquitoes A research team led by Prof. ZHENG Aihua from the Institute of Zoology of the Chinese Academy of Sciences revealed that N6-methyladenosine (m6A) epigenetic modifications in mosquito-borne…

#m6A #epigenetic modification controls #arbovirus #infection and transmission between #vertebrates and #mosquitoes ...

| #Arthropod | #arboviruses | #dengue | #pathogen | #Zika | #MicroSky | Via eurekalert .org

This review highlights #m6A #RNAmodification as a regulator of #RNAmetabolism and cellular processes, linking aberrant m6A to #cancer, #obesity, diabetes, and cardiovascular disease, and exploring m6A-targeted therapies for #MetabolicDisorders.

#OpenAccess: doi.org/10.1016/j.ge...

This review highlights the bidirectional role of FTO in #GastrointestinalCancers, regulating #OncogenicSignaling, immune evasion, and #DrugResistance, while pointing to FTO-targeted regulators and #AI-driven strategies for therapy. #m6A

#OpenAccess: doi.org/10.1016/j.ge...

This review elucidates the regulatory role of #m6A modification in #PCD pathways, highlighting its influence on #CardiovascularDisease progression and its emerging potential as novel diagnostic and #TherapeuticTarget.

#OpenAccess: doi.org/10.1016/j.ge...

#Molecular mechanisms underlying the #inhibition of #Sparassis latifolia #mycelial growth by #cycloleucine: a comprehensive #transcriptomic and #m6A methylome analysis
doi.org/10.1080/2150...
@tandfresearch.bsky.social

This review elucidates the reciprocal regulation of #m6A modifications and #ncRNAs, highlighting their critical roles in RNA metabolism and their potential as #TherapeuticTargets in various human diseases.

#OpenAccess: doi.org/10.1016/j.ge...

This review explores #m6A RNA modification and its crosstalk with others, detailing roles of writers, erasers & readers in regulating #geneexpression, disease, therapy response, and future RNA-based #biomarkers.

#OpenAccess: doi.org/10.1016/j.ge...

🧬 #NARGAB New Research Spotlight
Direct #RNA #nanopore sequencing reveals the most detailed #m6A map to date across Human immunodeficiency virus 1 transcripts #HIV-1. @cnrs.fr @i2bcparissaclay.bsky.social
👉 Read the full paper: doi.org/10.1093/narg...

Programmable epigenetic memory in action 🧬
Engineered m6A writer/reader proteins to initiate, read & propagate gene states in mammalian cells—without changing the DNA sequence.

📍 Epigenetics Congress 2026 (Hybrid)
🗓 Oct 15–16, 2026 | Boston, USA
🌐 epigeneticscongress.com

#SyntheticBiology #m6A

🧬 New Research: RMNet identifies m6A RNA modifications across species using nanopore sequencing & deep learning.

✅ No control samples needed ✅ Outperforms m6Anet & RedNano ✅ 89% accuracy in human data

Read: https://bit.ly/4pIbrv8

#Bioinformatics #ML #m6A #SciSky

N6‐Methyladenosine Modification of circIST1 Promotes Hypoxia‐Inducible Factor α–mediated Glycolysis and Progression in Hepatocellular Carcinoma We identified first time a critical m6A modification of circIST1 on miR-140-3p/miR-182-HIF1α regulatory network involved in the HCC progression and tumor glycolysis, gaining mechanistic insights into...

#Article in #MedComm
This article identified first time a critical #m6A modification of #circIST1 on miR-140-3p/miR-182-HIF1α regulatory network involved in the #HCC progression and #tumor #glycolysis. doi.org/10.1002/mco2...

Client Challenge

#Research
Activated oligoadenylate synthetase-ribonuclease L pathway promotes endothelial #pyroptosis and impairs diabetic wound healing via thioredoxin-interacting protein #m6A #methylation doi.org/10.1186/s435...

#OAS_RNaseL #TXNIP #LPS #DiabeticWound

This review highlights #IGF2BP1 as a key #m6A reader that drives #cancer hallmarks by promoting the translation of #oncogenic RNAs, linking its overexpression to poor prognosis and therapy resistance, and discussing its potential as a #biomarker.

#OpenAccess: doi.org/10.1016/j.ge...

This review examines the role of the #m6A writer #METTL16 in #cancer, detailing its m6A-dependent and independent regulation of #RNAmetabolism, links to #tumor growth, #metastasis and #DrugResistance, and its potential as a therapeutic target.

#OpenAccess: doi.org/10.1016/j.ge...

This review summarizes the role of #N6Methyladenosine RNA modification in #NeuralDevelopment and gene regulation, highlighting its involvement in #NeurodegenerativeDiseases & mechanisms linking #m6A to toxicant-induced #NervousSystemDisorders.

#OpenAccess: doi.org/10.1016/j.ge...

m6A RNA methylation is emerging as a key regulator in autoimmune diseases, shaping immune activation + new therapeutic avenues.
#Autoimmunity #m6A #Epigenetics #InflammationResearch
www.sciencedirect.com/science/arti...

Excited to share my first-ever publication, now out in @stemcellreports.bsky.social !! Heartiest congratulations to
Hemant and @barorunumi.bsky.social for jointly leading the work. Grateful to my PI, Srimonta for giving me this opportunity to contribute to this study.
#m6A #X:A_dosage @isscr.org

🧵(4/n)
Thanks to other contributors of this work
@amritesh-iisc.bsky.social and Murali. Special thanks to my collaborator Kartik Sunagar. Grateful to the reviewers and editors for their guidance throughout the process.
#Epigenetics #StemCell #RNAmodification #m6A

This work explores how m6A RNA methylation regulates embryonic stem cell (ESC) maintenance & differentiation — shedding light on epitranscriptomic mechanisms that influence pluripotency and cell fate.
#m6A #Epigenetics #StemCells #ESCs #RegenerativeMedicine
www.sciencedirect.com/science/arti...

Establishing benchmarks for quantitative mapping of m6A by Nanopore Direct RNA Sequencing. #DirectRNAseq #RNAsequencing #RNAmodifications #m6A #Genomics #Bioinformatics @nanoporetech.com 🧪🧬 🖥️
www.biorxiv.org/content/10.1...

This latest review highlights #m6A as a key regulator in #FemaleReproduction, shows how its dysregulation drives diverse infertility issues, and emphasizes that targeting m6A pathways could reshape #ReproductiveMedicine intervention. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Catch our latest blog on METTL Proteins here: 🔗 bit.ly/3IlTYco

📰 Our latest blog highlights how METTL14 modifies G6pc mRNA to regulate glucose metabolism in the liver — uncovering new insights into obesity and type 2 diabetes.
__________

#Epigenetics #RNA #m6A #DiabetesResearch #ObesityResearch

Why does the m6A writer complex require so many proteins? Post-transcriptional gene regulation through m6A deposition is dysregulated in many diseases and is catalyzed by a multi-protein writer complex. This Unsolved Mystery investigates why the writer compl...

Post-transcriptional #GeneRegulation through #m6A deposition is dysregulated in many diseases. Samie Jaffrey &co investigate why the m6A writer complex requires multiple subunits and what roles its individual proteins might have in m6A regulation. 🧪
plos.io/3VjfjWI

Why does the m6A writer complex require so many proteins? Post-transcriptional gene regulation through m6A deposition is dysregulated in many diseases and is catalyzed by a multi-protein writer complex. This Unsolved Mystery investigates why the writer compl...

Post-transcriptional #GeneRegulation through #m6A deposition is dysregulated in many diseases. Samie Jaffrey &co investigate why the m6A writer complex requires multiple subunits and what roles its individual proteins might have in m6A regulation. 🧪
plos.io/3VjfjWI

Why does the m6A writer complex require so many proteins? Post-transcriptional gene regulation through m6A deposition is dysregulated in many diseases and is catalyzed by a multi-protein writer complex. This Unsolved Mystery investigates why the writer compl...

Post-transcriptional #GeneRegulation through #m6A deposition is dysregulated in many diseases. Samie Jaffrey &co investigate why the m6A writer complex requires multiple subunits and what roles its individual proteins might have in m6A regulation. 🧪
plos.io/3VjfjWI

This review highlights dysregulated #m6A modifications in infertility-associated pathologies and suggests that modulation of m6A pathways could help address unmet clinical needs in #ReproductiveMedicine. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...

Imagined Liveries. SCM...

#slotcarsforlife #slotcarmods #slotcarmagazine #theartoftheslotcar #imagined #liveries #canada #canadian #mclaren #m6a #slotcarsofinstagram #slotcarphotography #slotcarcollecting #slotcar #slotcars #slotcartrack #slotcarcollection #slotcarracing

The crosstalk of m6A-modified RNA with DNA damage repair. #m6A #Epitranscriptomics #DNArepair @cp-trendsbiochem.bsky.social
www.cell.com/trends/bioch...

Methylation: Modifying gene expression through passive forces The mRNA metabolism passively shapes the levels of an mRNA modification called m6A within a steady-state cell and upon stress.

Please check out Sarah's "insight" comment on the work from Dierks & Schwartz lab: "Methylation: Modifying gene expression through passive forces"!

#RNA #m6A #modification #modelling

doi.org/10.7554/eLif...

Welcome to bluesky @zarnack-group.bsky.social !!!

#bioinformatics #RNA #splicing #RNAmodification #m6A