We recently welcomed two new members to our group @cbmr.science Postdoc Salim Hanna will be working on identifying translation-oriented approaches targeting #AMPK to improve muscle metabolic function. Research assistant, Frederik Gouliaev will be investigating AMPK and its phosphatases in the group.

This review summarizes how #lncRNAs regulate the #AMPK signaling pathway by interacting with DNA, RNA, and proteins, shaping cellular energy homeostasis, metabolism, #aging processes, and the development of #AgeRelatedDiseases.

#OpenAccess: doi.org/10.1016/j.ge...

✨New issue✨

Check out the latest in #Metabolism research from across all disciplines.

Read about #AMPK, #Cachexia, #ImmuneSignalling, #Microbiome, #NAD, #Nutrition, #TissueCrosstalk and many more topics! 🧪

www.nature.com/natmetab/vol...

How Two Cups of Green Tea Can Help You Burn Fat Naturally In today's episode we're exploring a simple yet powerful way to burn fat naturally by adding just one to two cups of green tea to your daily routine. We dive into how catechins like EGCG activate metabolic pathways such as AMPK to specifically target dangerous visceral fat surrounding your organs. You’ll learn why Matcha is the most effective variety, the optimal water temperature for brewing (80-85°C), and the best times to drink it to maximize fat oxidation during exercise. References: [1] https://www.youtube.com/watch?v=Jm07Xz2V2pI Become a supporter for just 2€ per month. This removes any advertisements and help us continue bringing more interesting topics and confronting mainstream narrative on health. Link to support: https://www.spreaker.com/podcast/foodnourish-deep-dives--6602003/support

📣 New Podcast! "How Two Cups of Green Tea Can Help You Burn Fat Naturally" on @Spreaker #ampk #brewing #caffeine #catechins #diet #egcg #exercise #fat #green #health #matcha #metabolism #natural #nutrition #oxidation #sencha #tea #visceral #weight #wellness

A new therapeutic strategy for osteoarthritis emerges by targeting the AMPK–β-catenin–Runx2 signaling axis.
#Osteoarthritis #AMPK #BetaCatenin #Runx2 #CartilageDegeneration #OAPathogenesis
doi.org/10.1016/j.ge...

AMPK regulates the anti-pulmonary fibrosis effects of tracheloside Idiopathic pulmonary fibrosis (IPF) presents limited therapeutic options that often involve severe side effects, making the development of innovative …

🫁 Can Tracheloside (TCL) slow pulmonary fibrosis?

A #CJNM study shows TCL activates AMPK, suppresses fibroblast differentiation, and reduces oxidative stress—a potential lead for IPF treatment. 🔬
🔗 Read it on ScienceDirect
#PulmonaryFibrosis #AMPK #NaturalProducts #CJNM

#Article in #MedComm
#Obestatin Treatment Counteracts #Muscle Wasting by Reactivation of #Autophagy in Duchenne Muscular Dystrophy (#DMD), studied by a research team from Complejo Hospitalario Universitario De Santiag
doi.org/10.1002/mco2...

#mTORC1 #AMPK #ULK1 #NEDD4 #VPS34

This review examines the roles of #LKB1/STK11 in #cancer, detailing its #TumorSuppressive functions, regulation via #AMPK signaling and #AdaptorProteins, and discusses the challenges of developing LKB1-targeted inhibitors. @westernu.bsky.social

#OpenAccess: doi.org/10.1016/j.ge...

Negative Impact of p21‐Activated Kinase 4‐Mediated AMP‐Activated Protein Kinase Inhibition on Sarcopenia in Mice and Humans PAK4 is overexpressed in muscle atrophy and negatively correlates with muscle mass and function in humans. Inhibiting PAK4 activates AMPK/PGC-1α-driven mitochondrial biogenesis by blocking AMPKα2-S4...

#Article in #MedComm
Negative Impact of p21-Activated Kinase 4-Mediated AMP-Activated Protein Kinase Inhibition on Sarcopenia in Mice and Humans doi.org/10.1002/mco2...

#AMPK #mitochondria #MuscleAtrophy #PAK4 #PROTAC

Skeletal muscle from TBC1D4 p.Arg684Ter variant carriers is severely insulin resistant but exhibits normal metabolic responses during exercise - Nature Metabolism In Greenlandic Inuit, a TBC1D4 loss-of-function mutation increases type 2 diabetes risk by tenfold. Carriers show severe muscle insulin resistance, impaired glucose disposal and reduced muscle GLUT4, ...

Effect of acute exercise in carriers of TBC1D4 mutation #myoblue #AMPK #insulin

www.nature.com/articles/s42...

The Anti-Aging Drug Debate: Miracle Cure or Dangerous Gamble? What if the cure for aging is already sitting in your local pharmacy? It's not science fiction—it's the explosive scientific debate that could change humanity forever. Are we truly one pill away from slowing aging? This podcast dives deep into the electrifying and controversial world of Metformin and Rapamycin, two powerhouse drugs that some scientists believe could be the key to unlocking unprecedented longevity. We cut through the hype to explore the hard science, breaking down how these molecules manipulate core aging pathways like AMPK and mTOR to potentially extend not just lifespan, but more importantly, healthspan. Join us as we investigate the promise and the peril. Can data from lab mice translate to humans? We'll tackle the tough questions about side effects, correct dosages, and the wild west of off-label use by biohackers. We'll also unpack the landmark TAME trial, the ambitious clinical study aiming to prove that aging itself can be treated. This isn't just a discussion about life extension; it's about the ethics, risks, and the revolutionary future of medicine. If you're fascinated by the cutting edge of human health and want to separate the scientific breakthroughs from the dangerous hype, hit that follow button now. The future of aging is here—are you ready for it?

📣 New Podcast! "The Anti-Aging Drug Debate: Miracle Cure or Dangerous Gamble?" on @Spreaker #ampk #antiaging #biohacker #biohacking #futureofmedicine #geroscience #healthoptimization #healthspan #healthtech #lifeextension #lifespan #longevity #longevityscience #metformin #mtor #rapamycin

Ketua TP PKK Kabupaten Kediri Beri Pendampingan pada Puluhan AMPK KUBUS.ID – Ketua TP PKK Kabupaten Kediri, Eriani Annisa Hanindhito memberikan pendampingan kepada puluhan anak yang memerlukan pendampingan khusus (AMPK) dengan menghadirkan psikolog. Mbak Cicha, sapaan akrabnya, mengungkapkan pada 2025 ini di Kabupaten Kediri AMPK berjumlah 73 anak, 30 di antaranya dihadirkan di Pendopo Panjalu Jayati untuk diberikan pendampingan secara langsung. Istri Bupati Kediri Hanindhito […]

Ketua TP PKK Kabupaten Kediri Beri Pendampingan pada Puluhan AMPK KUBUS.ID – Ketua TP PKK Kabupaten Kediri, Eriani Annisa Hanindhito memberikan pendampingan kepada puluhan anak yang memerlukan pendampingan khusus (AMPK) dengan menghadirkan psikolog. Mbak Cicha, sapaan akrabnya, mengungkapkan pada 2025 ini di Kabupaten Kediri AMPK berjumlah 73 anak, 30 di antaranya dihadirkan di Pendopo Panjalu Jayati untuk diberikan pendampingan secara langsung. Istri Bupati Kediri Hanindhito […]

Ketua TP PKK Kabupaten Kediri Beri Pendampingan pada Puluhan AMPK KUBUS.ID – Ketua TP PKK Kabupaten Kediri, Eriani Annisa Hanindhito memberikan pendampingan kepada puluhan anak yang memerlukan pendampingan khusus (AMPK) dengan menghadirkan psikolog. Mbak Cicha, sapaan akrabnya, mengungkapkan pada 2025 ini di Kabupaten Kediri AMPK berjumlah 73 anak, 30 di antaranya dihadirkan di Pendopo Panjalu Jayati untuk diberikan pendampingan secara langsung. Istri Bupati Kediri Hanindhito […]

Ketua TP PKK Kabupaten Kediri Beri Pendampingan pada Puluhan AMPK KUBUS.ID – Ketua TP PKK Kabupaten Kediri, Eriani Annisa Hanindhito memberikan pendampingan kepada puluhan anak yang memerlukan pendampingan khusus (AMPK) dengan menghadirkan psikolog. Mbak Cicha, sapaan akrabnya, mengungkapkan pada 2025 ini di Kabupaten Kediri AMPK berjumlah 73 anak, 30 di antaranya dihadirkan di Pendopo Panjalu Jayati untuk diberikan pendampingan secara langsung. Istri Bupati Kediri Hanindhito […]

Ketua TP PKK Kabupaten Kediri Beri Pendampingan pada Puluhan AMPK KUBUS.ID – Ketua TP PKK Kabupaten Kediri, Eriani Annisa Hanindhito memberikan pendampingan kepada puluhan anak yang memerlukan pendampingan khusus (AMPK) dengan menghadirkan psikolog. Mbak Cicha, sapaan akrabnya, mengungkapkan pada 2025 ini di Kabupaten Kediri AMPK berjumlah 73 anak, 30 di antaranya dihadirkan di Pendopo Panjalu Jayati untuk diberikan pendampingan secara langsung. Istri Bupati Kediri Hanindhito […]

Ketua TP PKK Kabupaten Kediri Beri Pendampingan pada Puluhan AMPK KUBUS.ID – Ketua TP PKK Kabupaten Kediri, Eriani Annisa Hanindhito memberikan pendampingan kepada puluhan anak yang memerlukan pendampingan khusus (AMPK) dengan menghadirkan psikolog. Mbak Cicha, sapaan akrabnya, mengungkapkan pada 2025 ini di Kabupaten Kediri AMPK berjumlah 73 anak, 30 di antaranya dihadirkan di Pendopo Panjalu Jayati untuk diberikan pendampingan secara langsung. Istri Bupati Kediri Hanindhito […]

Ketua TP PKK Kabupaten Kediri Beri Pendampingan pada Puluhan AMPK KUBUS.ID – Ketua TP PKK Kabupaten Kediri, Eriani Annisa Hanindhito memberikan pendampingan kepada puluhan anak yang memerlukan pendampingan khusus (AMPK) dengan menghadirkan psikolog. Mbak Cicha, sapaan akrabnya, mengungkapkan pada 2025 ini di Kabupaten Kediri AMPK berjumlah 73 anak, 30 di antaranya dihadirkan di Pendopo Panjalu Jayati untuk diberikan pendampingan secara langsung. Istri Bupati Kediri Hanindhito […]

🚨New publication alert: GDF15 alleviates diabetic endothelial dysfunction & oxidative stress through AMPK-dependent pathways. A promising therapeutic target for vascular protection in diabetes
doi.org/10.1016/j.vp...
#GDF15 #Diabetes #EndothelialHealth #OxidativeStress #AMPK

The AMPK-related kinase NUAK1 regulates neuronal morphogenesis through the RNA splicing co-factor SON In recent years, alternative splicing emerged as a major mechanism controlling gene-regulatory networks during brain development, yet how alternative splicing is tuned to the dynamic alterations under...

I am happy to share our latest work now posted on @biorxiv-neursci.bsky.social
We report that the #AMPK related kinase #NUAK1 teams up with splicing co-factor SON to regulate #RNAsplicing in developing cortical neurons, supporting axon growth and branching

www.biorxiv.org/content/10.1...

🎃Our October issue's out!
Cover: mechanoresponsive #microtubules

👉🏼Reviews: #CellularStress ; #NuclearPoreComplex & #mechanobiology
🔬 #StemCells #senescence #cancer #EndoplasmicReticulum #phagocytosis #pyroptosis #autophagy #PhaseSeparation #AMPK #chromatin & more!
www.nature.com/ncb/volumes/...

Amazing paper on how metabolites act as signaling factors which impact growth and development by ways which are not limited to merely changes in flux, energy production and biogenesis.
#Drosophila #metabolism #ecdysone #Ampk #interorgancommunication

Remote control of AMPK via extracellular adenosine controls tissue growth - Nature Cell Biology Zhang et al. demonstrate that AMPK can be activated by signalling metabolite, adenosine, under non-stress conditions during Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth.

💫NEW: @telemanlab.bsky.social & co demonstrate that #AMPK can be activated by signaling metabolite, #adenosine, under non-stress conditions during #Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth.
bit.ly/4gX6njF

ENPP1 governs the metabolic regulation of effector T cells in autoimmunity by detecting cytosolic mitochondrial DNA Ji et al. demonstrate an abnormal differentiation of effector T cells in human SLE, identifying new functions of ENPP1 as an mtDNA sensor and transcription factor. ENPP1 sensing of mtDNA promotes the ...

ENPP1 senses cytosolic mtDNA and promotes increased Slc2a1 and glucose uptake. Ultimately contributes to mal-differentiation of T cells in SLE #mTorc1 #AMPK

Cell Reports www.cell.com/cell-reports...

Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827 The mechanism and unique molecular/cellular features of the potent and selective AMPK inhibitor BAY-3827 are unraveled.

Latest publication from the lab spearheaded by @shoreseashell.bsky.social & in collaboration with @zeqiraj.bsky.social is out. Using structural, biochemical & computational tools, this work sheds light on the mechanism of action of BAY-3827 in inhibiting #AMPK 1/3
www.science.org/doi/full/10....

JCI Insight - Impaired AMPK control of alveolar epithelial cell metabolism promotes pulmonary fibrosis

Deficient #AMPK signaling in AT2 cell dysfunction as druggable signaling hub to mitigate #LungFibrosis in vivo insight.jci.org/articles/vie... #DrugDevelopment #PulmonaryResearch #TranslationalScience

☕ Tu CAFÉ activa el GEN de la LARGA VIDA ¿La nueva metformina natural? 🔬✨ #ciencia #salud #Café #Longevidad #CienciaDelCafé #Cafeína #SaludCelular #AMPK #Envejecimiento #Metformina #Microbiología #EstiloDeVidaSaludable #VidaLarga youtu.be/dmVA6Lz8KWg

Abnormalities of AMPK Activation and Glucose Uptake in Cultured Skeletal Muscle Cells from Individuals with Chronic Fatigue Syndrome Background Post exertional muscle fatigue is a key feature in Chronic Fatigue Syndrome (CFS). Abnormalities of skeletal muscle function have been identified in some but not all patients with CFS. To t...

Abnormalities of AMPK Activation and Glucose Uptake in Cultured Skeletal Muscle Cells from Individuals with Chronic Fatigue Syndrome
Audrey E. Brown, David E. Jones, Mark Walker, Julia L. Newton (2015) journals.plos.org/plosone/arti... #ME/CFS #AMPK

Pharmacological activation of AMPK and glucose uptake in cultured human skeletal muscle cells from patients with ME/CFS Skeletal muscle fatigue and post-exertional malaise are key symptoms of myalgic encephalomyelitis (ME)/chronic fatigue syndrome (ME/CFS). We have previously shown that AMP-activated protein kinase (AM...

Pharmacological activation of #AMPK and glucose uptake in cultured human skeletal muscle cells from patients with #ME/CFS pmc.ncbi.nlm.nih.gov/articles/PMC... (2018)

Biolexis Therapeutics Launches Pioneering GLP-1 and AMPK Clinical Trials for Metabolic Disease Treatments Biolexis Therapeutics has announced the start of first-in-human clinical trials for their innovative GLP-1 and AMPK programs, showcasing progress in metabolic disease treatment.

Biolexis Therapeutics Launches Pioneering GLP-1 and AMPK Clinical Trials for Metabolic Disease Treatments #USA #GLP-1 #Lehi #Biolexis #AMPK