📝 Now online - the Review "Molecular and structural mechanisms of nutrient sensing in the mTORC1 pathway" from @robzonculab.bsky.social and co.

#mTORC1 #PrimaryNutrientSensor #AminoAcidSensor #CholesterolSensor #Metabolites

Read it here: authors.elsevier.com/a/1mrsu_M0e4...

Cyst(e)ine in nutrition formulations promotes colon cancer growth and chemoresistance by activating mTORC1 and scavenging ROS.
Metabolism shapes therapeutic response.
doi.org/10.1038/s413...
#ColonCancer #CancerMetabolism #mTORC1 #ReactiveOxygenSpecies #Chemoresistance #TumorMetabolism

4E-BP1 deletion modestly mitigates mTORC1-deficient epidermal barrier defects https://ow.ly/OAcA50YhEYu #Dermatology #mTORC1
#Epidermis #BarrierFunction #dermsky

#Article in #MedComm
#Obestatin Treatment Counteracts #Muscle Wasting by Reactivation of #Autophagy in Duchenne Muscular Dystrophy (#DMD), studied by a research team from Complejo Hospitalario Universitario De Santiag
doi.org/10.1002/mco2...

#mTORC1 #AMPK #ULK1 #NEDD4 #VPS34

The latest research from our team is out in Cell @cp-cell.bsky.social! We used #cryo-EM, #imaging, #BRET, and #biosensors targeted to the lysosome to understand how the KICSTOR-GATOR1 complex turns off #mTORC1 in response to low levels of amino acids.

#mTORC1 inhibition activates the integrated stress response, upregulates pro-apoptotic BMF, and sensitizes resistant T-ALL to #Venetoclax; Everolimus–Venetoclax synergy reduces #leukemic burden in #PDXmodels. #medsky

#OpenAccess in #STTT: doi.org/10.1038/s413...

In #PI3K inhibitor-resistant #BreastCancer, aberrant #mTORC1 suppresses #autophagy, creating #MetabolicStress that sensitizes #tumors to #metabolicdrugs, while p-4E-BP1 and p62 accumulation serve as poor-survival #biomarkers.

#OpenAccess in #STTT: doi.org/10.1038/s413...

#HighFructose intake accelerates #InflammatoryBowelDisease by promoting Th1 and Th17 cell generation via #mTORC1 activation, while #metformin reverses this by suppressing these pathways, revealing its therapeutic potential in #colitis.

#OpenAccess #STTT: doi.org/10.1038/s413...

#Treg-derived IFNγ and #IL10 synergistically activate #mTORC1 and Myc pathways to promote epithelial repair, with combined #cytokine signaling supporting #IntestinalStemCell growth after therapy-induced #GutInjury. @tum.de @univparissaclay.bsky.social

#STTT: doi.org/10.1038/s413...

🦃Our November Issue is now out 🥧

📗 Cover: Cabezudo et al. IF staining in HEK293T of WAC, a regulator of mTORC1 in response to glucose and glutamine availability

🔦 Explore the contents here

🔓https://buff.ly/BaMtm3s

#Biochemstry #T2DM #mTORC1 #scRNAseq #Tamoxifen #ProstateCancer

ENPP1 governs the metabolic regulation of effector T cells in autoimmunity by detecting cytosolic mitochondrial DNA Ji et al. demonstrate an abnormal differentiation of effector T cells in human SLE, identifying new functions of ENPP1 as an mtDNA sensor and transcription factor. ENPP1 sensing of mtDNA promotes the ...

ENPP1 senses cytosolic mtDNA and promotes increased Slc2a1 and glucose uptake. Ultimately contributes to mal-differentiation of T cells in SLE #mTorc1 #AMPK

Cell Reports www.cell.com/cell-reports...

This study shows that #highfructose intake disrupts immune balance and aggravates #InflammatoryBowelDisease by promoting Th1/Th17 cell differentiation through #mTORC1 activation, while #metformin reverses these effects. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

How does nutrient-responsive #mTORC1 sense the key amino acid #glutamine?
Gianluca Figlia, Aurelio Teleman et al @telemanlab.bsky.social identify a combination of GCN2-dependent processes triggered by secondary depletion of asparagine in glutamine-starved cells
www.embopress.org/doi/full/10....

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

👉 buff.ly/IoEPOTs

🥼 @OscarLlorcaCNIO @CNIOStopCancer

#mTORC1 #CellMetabolism #Chaperones

Review From William T. Festuccia, #mTORC1 and 2 Adrenergic Regulation and Function in Brown Adipose Tissue, doi.org/10.1152/phys...
#BrownAdiposeTissue

#Medsky🧪 #oncosky #immunosky #publichealth #Linoleicacid is the most abundant polyunsaturated fatty acid in the Western-style diet & has been implicated in promoting #inflammation & #cancer.
#Linoleicacid can activate #mTORC1 #proteinkinase which coordinates growth & nutrient signals @science.org

Figure showing whole-body metabolic effects of constitutive genetic overactivity or inhibition of mTORC1 in skeletal muscle.

Here, Daniela Cota and colleagues review current evidence illustrating the critical role of #mTORC1 signalling in the regulation of energy expenditure and adaptive thermogenesis (£) go.nature.com/3OeQEPK

Spinal 5-HT7 receptors induce phrenic motor facilitation via EPAC- #mTORC1 signaling #rapamycin #MECFS #LongCovid

bsky.app/profile/rene...

Spinal 5-HT7 receptors induce phrenic motor facilitation via EPAC-mTORC1 signaling Spinal serotonin type 7 (5-HT7) receptors elicit complex effects on motor activity. Whereas 5-HT7 receptor activation gives rise to long-lasting phrenic motor facilitation (pMF), it also constrains 5-...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"Finally, spinal mammalian target of rapamycin complex-1 ( #mTORC1) inhibition via intrathecal rapamycin abolished 5-HT7 receptor- and EPAC-induced pMF, demonstrating that spinal 5-HT7 receptors elicit pMF by an EPAC-mTORC1 signaling pathway."

Frontiers | Targeting Pyrimidine Metabolism in the Era of Precision Cancer Medicine Metabolic rewiring is considered as a primary feature of cancer. Malignant cells reprogram metabolism pathway in response to various intrinsic and extrinsic ...

increased nucleotide synthesis, pyrimidines. Pyrimidines are synthesized through de novo & salvage pathways
www.frontiersin.org/journals/onc...
#mTORC1 controls the half-life of uridine cytidine kinase 2 (UCK2), the rate-limiting enzyme in the salvage pathway
www.frontiersin.org/journals/onc...

#research #mTORC1 #RagGTPases

Rag–Ragulator is the central organizer of the physical architecture of the mTORC1 nutrient-sensing pathway (Sabatini) -
@pnas.org: pnas.org/doi/10.1073/...

#MGHMedicine @iocbprague.bsky.social @whiteheadinstitute.bsky.social @harvardmed.bsky.social

The PDBs for our TSC structure are now available!

To put the size of TSC in perspective, here's a ribosome... this thing is enormous. 🤩

#cryoEM #mTORC1 #TSC

rcsb.org/3d-view/9CE3
science.org/doi/10.1126/sciadv.adr5807
@luptoncj.bsky.social

Reciprocal regulation of mTORC1 signaling and ribosomal biosynthesis determines cell cycle progression in activated T cells Interplay between signaling pathways and ribosomal biogenesis supports the proliferation of activated T cells.

Reciprocal regulation of #mTORC1 signaling and #ribosomal biosynthesis determines #cellcycle #progression in activated #T_cells: www.science.org/doi/10.1126/...

mTOR on the Move Eating less, intermittent fasting, anti-ageing drugs such as rapamycin - there is a lot of public advice on preventing age-related diseases. A central regulator that appears to be linked to all these ...

🔍 mTORC1 Research: New Findings Challenge Old Model 🧫🧪Congrats to the Demetriades Lab team! #mTORC1 #Research

And special thanks to @sofiaahola.bsky.social for the great picture!

www.age.mpg.de/415628/24112...

On the cover #MolecularCell. In this issue Acharya and Demetriades show how #mTORC1 🎈activation mediates its own release from the #lysosomes 🪐🌎. It was my pleasure to bring to life the grand idea from Aishwarya and Costas!

Page not found - Impact Journals

(PDF) #mTORC1 sustains vision in retinitis pigmentosa www.impactjournals.com/oncotarget/index.php #RP