The #cytoskeleton contributes to abnormal genome-lamina interactions in LMNA-deficient cardiomyocytes. New study from Kaitlyn M. Shen, Parisha P. Shah, Rajan Jain @pennmedicine.bsky.social and colleagues: rupress.org/jcb/article/...

#Chromatin #epigenetics #Disease #lamin #laminopathies

Epigenetics Update - Glucocorticoids elevate clear cell renal cell carcinoma sensitivity to HIF-2α inhibitors by suppressing H4K12 lactylation go.nature.com/4m76wDC

#Epigenetics #Lactylation #Chromatin #Cancer
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High-resolution insights without cell sorting; epigenometech.com

Image of a planarian, from Wiki.

Do you do a PhD on Chromatin in this cool critter?

Work with @jordisolana.bsky.social @seanflynn.bsky.social, Magda Strauss and myself @lsiexeter.bsky.social on developing #singlecell #chromatin analyses to better understand pluripotency #planarians.
www.exeter.ac.uk/research/ins...

This review highlights how #histone #PostTranslationalModifications dynamically regulate #chromatin and gene expression in #CVDs, revealing their mechanistic roles and therapeutic potential alongside current challenges and future prospects.

#OpenAccess: doi.org/10.1016/j.ge...

Prof. Javier Rodriguez-Casariego's fascinating seminar, "Epigenetic Mechanisms of Rapid Environmental Plasticity in Reef-Building Corals", is now available for viewing on the CPGE YouTube channel. Enjoy!

#epigenetics #chromatin #genomics #corals #northwestern #reefs #science

youtu.be/lcp9TyW8UTs

Chromatin organization in Asgard archaea: histones, SMC complexes, and the archaeal roots of eukaryotic chromatin
#microbiology #genetics #genome #chromatin #archaea #eukaryotes #MicroSky
@cp-trendsgenetics.bsky.social
www.sciencedirect.com/science/arti...

Epigenetics Update - Chromatin accessibility regulates age-dependent nuclear mechanotransduction bit.ly/4m0qhwH

Yawen Liao and G. V. Shivashankar from ETH Zurich in PNAS

#Epigenetics #Chromatin #Aging #Mechanotransduction
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Empower your research at epigenometech.com

🆕 ADVANCE ONLINE 🆕

RESEARCH PAPER: Bypass of blocking lesions by RNAPII reveals a novel stress induced by DNA damage
By Bañuelos et al. and Ramiro Verdun
➡️ https://ow.ly/ZfMy50YAOS1


#chromatin #histone #epigenetics #cellstress #chemotherapy

We are now on Substack!

Come find us at epigenometech.substack.com for our long-form pieces!

#EpigenomeTech #Blogs #Substack #PairedTag #SingleCell #Multiomics #Chromatin

Epigenetics Update - The XSER1 lncRNA acts as an enhancer RNA and confers resistance to pathogens by promoting chromatin loop formation in rice bit.ly/3NNJlBK

#Epigenetics #LncRNAs #Chromatin #EnhancerLoop #Rice #Plants
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High-resolution insights without cell sorting; epigenometech.com

🧬 Epigenetics & Gene Regulation
🔬 Chromatin structure, DNA methylation & histone modifications control gene expression.

📢 Epigenetics Congress 2026
📅 Oct 15–16, 2026 | 📍 Boston, USA
🌐 epigeneticscongress.com

#Epigenetics #Chromatin #GeneExpression

NPC remodeling drives #osteoclastogenesis by reshaping #chromatin architecture and epigenetic accessibility, with Nup133, Dnmt3a, and Ezh2 emerging as key regulators of #osteoclast differentiation and promising therapeutic targets for #BoneDiseases.

Read: doi.org/10.1016/j.ge...

Condensin accelerates long-range intra-chromosomal interactions - Nature Communications Long‑range chromosome encounters in cells are hard to quantify. Here, the authors induce artificial contacts in yeast and show that intra‑chromosomal interactions form faster than inter‑chromosomal ones in G1 yeast, driven by condensin‑mediated loop extrusion.

Condensin accelerates long‑range intra‑chromosomal interactions in budding yeast. Using CICI to measure encounter times across loci, the study provides a dynamic view of chromatin motion beyond static 3C snapshots. #NatureCommunications #Chromatin #YeastResearch

Epigenetics Update - Species-specific chromatin architecture and neurogenesis mediated by a human enhancer bit.ly/3PhxTig

Debra L. Silver (Duke University) in Cell Stem Cell

#Epigenetics #Chromatin #Enhancers
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Perfect for cancer, immunology, and aging research; epigenometech.com

👋Our March issue is out!
Cover: #Adipose – #tumor in #immune escape

👉Reviews on: #metabolism #hematopoiesis ; #amnion ; #brain #lipids
🔬 #mitochondria #LipidDroplets #aging #autophagy #mechanobiology #neurodegeneration #ferroptosis #chromatin #metastasis & more!
www.nature.com/ncb/volumes/...

🆕 ADVANCE ONLINE 🆕

RESEARCH COMMUNICATION: Chromatin architecture reprogramming reveals novel epigenetic dependencies in breast cancer
By Garcia-Martinez et al. and Lluis Morey
➡️ genesdev.cshlp.org/content/early/2025/12/18...

Lluis Morey
#chromatin #transcription

⏰ Deadline approaching!
Apply now for the Chromatin Biology Summer School 2024 and join an inspiring week of science, learning, and community.
Submit before March 29th to be considered for this exciting opportunity: bit.ly/4oGDR8f
#chromatin #summerschool

Epigenetics Update - Histone modification clocks for robust cross-species biological age prediction and elucidating senescence regulation bit.ly/4umW1A3

Lei Gu reporting in PNAS

#Epigenetics #Chromatin #Aging #HisMods
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Empower your research with hi-res epigenetic insights at epigenometech.com

Unstructured transcription factor interactions enable emergent specificity How intrinsically disordered regions (IDRs) influence chromatin binding and nuclear organization of transcription factors (TFs) remains unclear. We employed proximity-assisted photoactivation (PAPA), ...

While #DNAbindingdomains & #IntrinsicallyDisorderedRegions individually do not show binding specificity, "ensembles of diverse, unstructured interactions" collectively enable emergent #TranscriptionFactor specificity ➡️ www.science.org/doi/10.1126/...
#generegulation #IDRs #TFspecificity #chromatin

At #EMBLTranscript, experts will share breakthroughs across the full spectrum of #transcription – from cis-regulatory function and long-range regulation to 3D looping, basal transcriptional machinery, #chromatin modifications, #epigenetic inheritance, and more 🧬

Join us: s.embl.org/trm26-01-bl

A functional overlap between actively transcribed genes and chromatin insulator elements - The EMBO Journal The mammalian genome is organised into large topologically associating domains (TADs) and smaller sub-TADs or enhancer-promoter loops, which may contribute to the regulation of gene expression. These ...

#WIMMReads
🧪 From Jim Hughes, Douglas Higgs and Mira Kassouf: actively transcribed genes can define chromatin boundaries, linking gene activity directly to 3D genome organisation.

Read more 👇

#GenomeBiology #Chromatin #WIMM @rdm.ox.ac.uk @medsci.ox.ac.uk #AkademicSky

Our expansion of single-cell epigenetics assays continues!

The Epigenome Technologies scCUT&Tag assay is now compatible with the BD Rhapsody platform

Learn more here: bit.ly/4lquJDv

#Epigenetics #BDrhapsody #CUTandTag #Chromatin #Multiomics #Singlecell #CUTandRUN #ChIPseq #ATACseq

Inflammatory signaling differentially changes #chromatin accessibility and #gene expression of the PD-associated kinase #LRRK2 between human and mice

Alexandra Beilina, Jae-Hyeon Park, Natalie Landeck...Mark R. Cookson @markrcookson.bsky.social #Parkinsons

link.springer.com/article/10.1...

A mechanism to initiate emergency type 2 myelopoiesis - Nature Myelopoiesis in response to a parasitic worm infection and the mechanism selective to this form of parasite are revealed.

Epigenetics Update - A mechanism to initiate emergency type 2 myelopoiesis go.nature.com/4umufn4

Claus Nerlov (University of Oxford) reported in Nature

#Epigenetics #Myelopoiesis #Chromatin
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Empower your research with high-res epigenetic insights at epigenometech.com

🍀 Feeling lucky this St. Patrick’s Day?

At EpiCypher, we know great science isn’t luck — it’s built on the right reagents, assays, and expertise.

Here’s to a little luck and a lot of good science. Happy St. Patrick’s Day! 🧬🍀

#StPatricksDay #Epigenetics #Chromatin #EpiCypher

In the most recent episode we talked with Oliver Bell from UCLA about his work on chromatin-based regulatory systems that encode cellular memory and their implications for development and disease. #podcast #epigenetics #chromatin

Listen here: activemotif.com/podcasts-oli...

Self-clustering of three CBX2 molecules drives PRC2 to promote facultative heterochromatinization of Polycomb target genes Phase separation is increasingly recognized in facultative heterochromatinization of Polycomb target genes; however, the mechanisms underlying this pr…

🆕CBX2 drives PRC2 to form condensates. I wonder what its plant #chromatin paralog would be.
www.sciencedirect.com/science/arti...

Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains The Polycomb repressive complex 2 (PRC2) is essential for normal development by maintaining developmental gene repression. PRC2 deposits the repressiv…

🆕Allosteric regulatory activity of JARID2 & PALI1 is required to restrict the uncontrolled spread of PRC2 #chromatin domains
www.sciencedirect.com/science/arti...

Epigenetics Update - Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis bit.ly/4bl0b2r

Bogdan Bintu (UCSD) and Alexander F. Schier (Uni. Of Basel) reporting in Science

#Epigenetics #Chromatin #Embryos
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Empower your research at epigenometech.com

In this episode of the Epigenetics Podcast, we talked with Oliver Bell from UCLA about his work on chromatin-based regulatory systems that encode cellular memory and their implications for development and disease. #podcast #epigenetics #chromatin

Listen here: activemotif.com/podcasts-oli...