Promising new approach from @mskcancercenter.bsky.social : uPAR-targeted #CARTcells tackle both #tumor cells and their microenvironment, showing strong preclinical activity in solid #tumors and #metastases. www.linkedin.com/posts/drmelv...
Oben: Porträt von Albrecht Stenzinger. Im Hintergrund ist ein histopathologisches Bild eines Compound-Nävus zu sehen. Unten: Die Überschrift des im Post verlinkten Artikels "Diversität für die Pathologie“, gefolgt von dessen Vorspann „Genomik und Transkriptomik gehören routinemäßig zur Diagnostik von Tumor-Erkrankungen. Hinzu kommen digitale Weiterentwicklungen, weiß Albrecht Stenzinger.“ Links daneben befindet sich ein Icon mit Smartphone und Magazinseite sowie der Schriftzug „Kostenlos online lesen!“. In der rechten unteren Ecke befindet sich das Laborjournal-Logo.
Ausschnitt des verlinkten Artikels.
Die #Pathologie ist diverser als ein Gerichtsmediziner, der im Keller eine Obduktion vornimmt. #Morphologie, #Genomik, #Transkriptomik, #Proteomik... Albrecht Stenzinger der @uniheidelberg.bsky.social Uniklinik erläutert Genaueres im Interview: www.laborjournal.de/editorials/3...
#LifeSci #Tumor
TUG1 drives #chondrosarcoma progression by stabilizing EZH2 via ALYREF and promoting H3K27me3-mediated CPEB1 repression, while exosomal TUG1 enhances M2 #MacrophagePolarization, fueling #tumor growth and #metastasis.
#OpenAccess: doi.org/10.1016/j.ge...
#SLC27A5 suppresses #HCC progression by regulating APA via PABPC1 to enhance #METTL14 expression, reducing #tumor stemness, while its deficiency predicts poor prognosis and highlights a novel metabolic–RNA processing therapeutic axis in HCC.
#OpenAccess: doi.org/10.1016/j.ge...
A team of researchers have used pig semen to develop eye drops that can stop #tumor growth in the retina & preserve vision! This mouse study could pave the way for the development of drops to treat children with #retinoblastoma. #Cancer #Ophthalmology
www.nature.com/articles/d41...
Single-cell and #SpatialTranscriptomics of primary testicular #DLBCL reveal an exhausted CD8⁺ T cell–dominated microenvironment and spatial immune architecture, with E2F and CREB inhibition suppressing #lymphoma proliferation and #tumor growth.
#OpenAccess: doi.org/10.1016/j.ge...
"Scientists have uncovered a hidden reason why #cancer #treatments don't work equally well for every1. Certain drugs can become trapped inside #lysosomes within #tumor #cells, forming slow-release reservoirs that create uneven drug distribution.": buff.ly/VYnYLjj
via sciencedaily
#CancerResearch
This review highlights aberrant #neddylation as a driver of #HepatocellularCarcinoma, influencing infection, #tumor growth, invasion, and the #TumorMicroenvironment, while assessing inhibitors like MLN4924 & TAS4464 as promising #HCC therapies.
#OpenAccess: doi.org/10.1016/j.ge...
Für seine wegweisenden Beiträge zur Erforschung kindlicher Hirntumoren ist der Wissenschaftler und Kinderonkologe Prof. Dr. Stefan Pfister mit dem Thomas und Doris Ammann-Preis ausgezeichnet worden.
Stefan Pfister für wegweisende Beiträge zur Erforschung kindlicher Hirntumoren ausgezeichnet: Der Heidelberger Wissenschaftler und Kinderonkologe erhält den Thomas und Doris Ammann-Preis www.uni-heidelberg.de/de/newsroom/... #uniheidelberg #tumor #onkologie #dkfz @dkfz.bsky.social
In Cancer Biology & Medicine, this expert consensus outlines how TMB should be defined, tested, standardized, and clinically interpreted to improve its use in real-world cancer immunotherapy practice in China.
#Biomarkers #Tumor immunotherapy
Details: doi.org/10.20892/j.i...
What characterizes cancer? #oncology #cancer #tumor #carcinogen ... Continue to: www.facebook.com/reel/1247037...
This review shows how #RNAbindingProteins and #circularRNAs form regulatory networks driving #tumor traits like #metastasis & #DrugResistance, offering therapeutic insights via RNA technologies to reshape the #TumorMicroenvironment.
#OpenAccess: doi.org/10.1016/j.ge...
Close-up of JAMA journals with "jama.com JAMA Research Opinion Viewpoint" text, "Tumor Debulking in Metastatic Colorectal Cancer, Physical... JAMA Editors' Summary", and a play button.
In under 10 minutes, JAMA Deputy Editors Linda Brubaker, MD, and Preeti Malani, MD, MSJ, discuss the latest science published in JAMA:
➡️ #Tumor Debulking in Metastatic #ColorectalCancer,
➡️ Physical Restraints in the #ICU, and more
Listen now: ja.ma/4boALCy
How is cancer classified? #oncology #cancer #tumor #cancerclassification
... Continue to: youtube.com/shorts/rCANp...
Struktur in der Viszeralchirurgie: Sven Henne (Krankenhaus Rummelsberg) erklärt im Interview, wie ein Behandlungspfad und interdisziplinäre Tumorkonferenzen die bestmögliche Versorgung bei gastrointestinalen Tumoren sicherstellen.
#Rummelsberg #LeadingMedicineGuide #Tumor
👋Our March issue is out!
Cover: #Adipose – #tumor in #immune escape
👉Reviews on: #metabolism #hematopoiesis ; #amnion ; #brain #lipids
🔬 #mitochondria #LipidDroplets #aging #autophagy #mechanobiology #neurodegeneration #ferroptosis #chromatin #metastasis & more!
www.nature.com/ncb/volumes/...
😰 Marvvila sente dor intensa após tirar tumor e vai às pressas a médico
📲 www.ibahia.com/diversao/nem...
#Ibahia #Marvvila #Tumor
Engineering #TCR #catch #bonds for #tumor #immunity.
@science.org
Chris Garcia @stanforduniversity.bsky.social @hhmi-science.bsky.social
Owen Witte @uclastemcell.bsky.social
Brian Evavold @utah.edu
www.science.org/doi/10.1126/...
"Their #research shows that a bacterium commonly associated with #GumDisease may help initiate #BreastCancer, accelerate #tumor growth, and promote its spread by damaging DNA and changing how #CancerCells behave.": buff.ly/k7H74R8 via @sciencedaily
#cancer #MedSky #OralHealth #OralHygiene #bacteria
❤️🩹Saiba o real estado de saúde de Marvvila após descoberta de tumor
📲 ibahia.com/diversao/nem...
#Ibahia #Marvvila #Tumor
A new approach to #colorectal #cancer treatment using common #food-borne #bacteria ...
| #tumor | #microbes | #Listeria | #Toxin | #MicroSky | By @baylor.bsky.social via @sciencex.bsky.social
Gene Expression Profile Identifies LncRNA AL355974.3 As a Potential Glioma Biomarker
This study investigates #lncRNA expression in #Glioma tissue, functions of differentially expressed lncRNAs, their roles in #Tumor progression, & their potential to inform future research to identify #Biomarkers for diagnosis and treatment. #medsky
To read: doi.org/10.1007/s115...
Smart pivot: using #immunecell behavior instead of chasing #tumor cells. Leukocyte adhesion as a signal for relapse + #chemotherapy treatment response is a big step toward real-time #cancer monitoring. www.linkedin.com/posts/drmelv...
This review highlights the role of #FattyAcidOxidation in #cancer, showing how mitochondrial regulation of energy and signaling drives #tumor growth and #metastasis, positioning FAO as a promising therapeutic target.
#OpenAccess: doi.org/10.1016/j.ge...
USP7-mediated deubiquitination and nuclear translocation of PFKM promotes brain tumor development by sensing fructose-2,6-bisphosphate. USP7 interacts with PFKM regulated by F-2,6-BP, resulting in the ubiquitination of PFKM K615 after GD treatment. Deubiquitinated PFKM translocates into nucleus and interacts with c-Myc. PFKM facilitates c-MYC binding to CPT1B promoter and promotes transcription of CPT1B, thereby enhancing FAO and cell survival.
How does nutrient deficiency in the #tumor #microenvironment lead to metabolic reprogramming? This study reveals a mechanism for glioblastoma survival via switching from #glycolysis to #FattyAcid oxidation in mice, with implications for cancer medicine @plosbiology.org 🧪 plos.io/3P6pSg4
USP7-mediated deubiquitination and nuclear translocation of PFKM promotes brain tumor development by sensing fructose-2,6-bisphosphate. USP7 interacts with PFKM regulated by F-2,6-BP, resulting in the ubiquitination of PFKM K615 after GD treatment. Deubiquitinated PFKM translocates into nucleus and interacts with c-Myc. PFKM facilitates c-MYC binding to CPT1B promoter and promotes transcription of CPT1B, thereby enhancing FAO and cell survival.
How does nutrient deficiency in the #tumor #microenvironment lead to metabolic reprogramming? This study reveals a mechanism for glioblastoma survival via switching from #glycolysis to #FattyAcid oxidation in mice, with implications for cancer medicine @plosbiology.org 🧪 plos.io/3P6pSg4
What characterizes cancer? #oncology #cancer #tumor #carcinogen ... Continue to: www.facebook.com/reel/1481663...
