A distinct metabolic signature of #nucleic acid sensing: Unlike TLR ligands, #cytosolic nucleic acid sensing (#STING/#MAVS) or direct IFN I decreases mitochondrial membrane potential (MMP) without collapsing #OXPHOS. Measured by TMRM/JC 1; OCR remains intact. #immunosky

Silencing YAP/TAZ lowers SOX2 in #Mammospheres, reducing sphere formation and viability, modulating #RedoxHomeostasis, regulating mitochondria, and via DRP1 impairing #OXPHOS to eliminate #chemoresistant #brCSCs.

#STTT #OpenAccess: doi.org/10.1038/s413...

This review highlights recent advances in #EnergyMetabolism, detailing key pathways like #glycolysis, #OXPHOS, and #FAO, their dysregulation in diseases, and emerging strategies for precision treatment. #multiomics #CRISPR #medsky

#OpenAccess in #STTT: doi.org/10.1038/s413...

The Power Struggle: Kynurenine Pathway Enzyme Knockouts and Brain Mitochondrial Respiration Kynurenine pathway enzyme knockouts impair mitochondrial respiration. The deletion of kynurenine aminotransferase genes leads to significant impairment of mitochondrial respiration and ATP production...

💥🧬Lose KATs→lose energy!🧠🔥 In kat1-/-, kat2-/- & kat3-/- mice #Cerebellum, #Hhippocampus & #Striatum show crippled #OXPHOS & #ATP drops⚡❗ #Neuroscience #Mitochondria
doi.org/10.1111/jnc....

Our new preprint is out! We discovered a novel survival strategy for cells with mitochondrial defects. By sequestering toxic fats in lipid droplets, they protect themselves from ferroptosis. Lipid droplets as cellular bodyguards! 💪 #mitochondria #metabolism #ferroptosis #OXPHOS

#zebrafish #regeneration #heart #OXPHOS #devbio #differentiation
@natcardiovascres.nature.com @idrm.ox.ac.uk @oxforddpag.bsky.social

The Power Struggle: Kynurenine Pathway Enzyme Knockouts and Brain Mitochondrial Respiration Kynurenine pathway enzyme knockouts impair mitochondrial respiration. The deletion of kynurenine aminotransferase genes leads to significant impairment of mitochondrial respiration and ATP production....

💥🧬Lose KATs→lose energy!🧠🔥 In kat1-/-, kat2-/- & kat3-/- mice #Cerebellum, #Hhippocampus & #Striatum show crippled #OXPHOS & #ATP drops⚡❗ #Neuroscience #Mitochondria
doi.org/10.1111/jnc....

It All Comes Down to the Mitochondria

Sleep: It All Comes Down to the Mitochondria
www.science.org/content/blog...
news.ycombinator.com/item?id=4473...
#DerekLowe

Mitochondrial origins of the pressure to sleep
www.nature.com/articles/s41...

#mitochondria #OXPHOS #metabolism #sleep #CellBiology #MolecularBiology #ATP

An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s disease Harhai and collaborators expand the catalog of genes essential for oxidative phosphorylation and implicate FAM136A in mitochondrial proteostasis. Their findings suggest a mitochondrial contribution to...

Here it is❗️Our updated inventory of genes required for #OXPHOS & findings on #mito defects in #Menieres is now out at Cell Reports by Cell Press! 🎉
 
Thank you to all of our collaborators and funding sources, this was a great and exciting project from start to finish. 💫

www.cell.com/cell-reports...

An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s disease Harhai and collaborators expand the catalog of genes essential for oxidative phosphorylation and implicate FAM136A in mitochondrial proteostasis. Their findings suggest a mitochondrial contribution to...

Our updated inventory of genes required for #OXPHOS & findings on #mito defects in #Menieres is now out at Cell Reports! 🎉

🧫 New galactose #CRISPR screen
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂 Mito defects in #Menieres

www.cell.com/cell-reports...

Swapping one sugar for another leads stem cells to become 'fitter and younger' versions of themselves, new research has revealed. Dr Semyon Bodian writes more about these super stem cells on our website: www.progress.org.uk/swapping-one...

#stemcells #metabolism #sugar #oxphos #glycolysis

Oncogenic TFE3 fusions drive OXPHOS and confer metabolic vulnerabilities in translocation renal cell carcinoma - Nature Metabolism Li et al. show that the TFE3 driver fusion transcriptionally upregulates an OXPHOS programme in translocation renal cell carcinoma that renders this cancer vulnerable to reductive stress, induced by imbalance of reducing equivalents.

RESEARCH | @liron1bar-peled.bsky.social @srviswanathan.bsky.social et al. ( @danafarber.bsky.social ):

The TFE3 driver fusion upregulates an #OXPHOS programme in renal cell carcinoma that renders this #cancer vulnerable to reductive stress🧫

Natural killer loops: pyruvate in, lactate out - Nature Metabolism

NEWS&VIEWS | C Deane & @davidfinlaytcd.bsky.social (Trinity College Dublin):

The authors discuss a study which shows that natural killer cells take up exogenous pyruvate to support #glycolysis and #oxphos 🧫

https://bit.ly/3Flz76S

We focus on #FAM136A, an orphan protein involved in familial #Menieres, an inner ear condition – not considered to be a mito disease!

We show that in #FAM136A ko:
⬇️IMS protein #CLPB #HAX1
⬇ #OXPHOS in cells, mice and patient LCLs

A #mito origin in #Menieres disease?!?

3/5

Our updated inventory now contains more genes related to #OXPHOS and pathways such as #mitodynamics, #import, #proteostasis and #transport.

It also retrieved 157 known mito disease genes
➡️ 157 positive controls! 🤯

2/5

New preprint from the lab! 🚨

🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease

by @marcellharhai.bsky.social @fbm-unil.bsky.social

A short thread 1/5

www.biorxiv.org/content/10.1...

#mecfs #mitochondria #oxphos

Copper drives remodeling of metabolic state and progression of clear cell renal cell carcinoma Abstract. Copper (Cu) is a cofactor of cytochrome c oxidase (CuCOX), indispensable for aerobic mitochondrial respiration. This study reveals that advanced clear cell renal cell carcinomas (ccRCCs) acc...

#kidneycancer seems to accumulate copper to help drive #OXPHOS energy metabolism, but then must also guard against #ROS oxygen free radicals from this copper load. Can this help us design prevention and treatment strategies? doi.org/10.1158/2159...

Krebs cycle derivatives, dimethyl fumarate and itaconate, control metabolic reprogramming in inflammatory human microglia cell line Metabolic reprogramming drives inflammatory activity in macrophages, including microglia, with Krebs cycle (KC) intermediates playing a crucial role a…

#mecfs #oxphos #mitochondria

This study might be of interest?

www.sciencedirect.com/science/arti...
Krebs cycle derivatives, dimethyl fumarate and itaconate, control metabolic reprogramming in inflammatory human microglia cell line

More on DMF: www.epiphanyasd.com/search/label...