Digestive cancers: mechanisms, therapeutics and management

This study shows that phosphorylated TLR3 translocates to the nucleus and activates PRMT5–c-Myc signaling, enhancing #Metastasis and #Chemoresistance, with elevated nuclear TLR3 levels correlating with poor prognosis.
#STTT #OpenAccess: doi.org/10.1038/s413...

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Cyst(e)ine in nutrition formulations promotes colon cancer growth and chemoresistance by activating mTORC1 and scavenging ROS.
Metabolism shapes therapeutic response.
doi.org/10.1038/s413...
#ColonCancer #CancerMetabolism #mTORC1 #ReactiveOxygenSpecies #Chemoresistance #TumorMetabolism

#Ubiquitin-mediated stabilization of KDM5B promotes #Chemoresistance in #OvarianCancer by repressing DUSP4 and activating MAPK signaling, highlighting the KDM5B/DUSP4 axis as a #TherapeuticTarget for overcoming #Cisplatin resistance.
#STTT #OpenAccess: doi.org/10.1038/s413...

This review shows how #MitochondrialDysfunction in dynamics and energetics drives #TNBC progression and #chemoresistance, while targeted strategies restoring homeostasis and disrupting #TumorMetabolism offer therapeutic promise.

#OpenAccess: doi.org/10.1016/j.ge...

#CryoEM reveals NADK tetramer regulation of NAD+/NADP+ balance; mutations alter activity—R45H boosts function and drives #chemoresistance, while loss-of-function variants enhance #chemotherapy sensitivity, linking NADK structure to #cancer.

#OpenAccess: doi.org/10.1016/j.ge...

This review highlights how #GlutathioneSTransferases regulate detoxification and #homeostasis, with dysregulation or polymorphisms driving #cancer, #neurodegeneration, and #chemoresistance, highlighting them as precision therapeutic targets. @qu_uni

Read: doi.org/10.1016/j.ge...

This study investigates how USP11-mediated stabilization of KDM5B drives #Chemoresistance in #OvarianCancer by repressing DUSP4, uncovering a novel #Epigenetic mechanism with potential therapeutic implications.

#STTT #OpenAccess: doi.org/10.1038/s413...

This #STTT study shows that #Osimertinib disrupts the MYLK4–CDKAL1 interaction, inhibits pT43-CDKAL1 phosphorylation, and CDKAL1-dependent SALL2 translation to inhibit #CancerStemness & #Chemoresistance in #Rhabdomyosarcoma.

#OpenAccess: doi.org/10.1038/s413...

#CircularRNA #ChemoResistance

Circ76691 (1 of 6 cirRNAs⏫in #Oxaliplatin resistance #ColoRectalCancer in vitro, also⏫in vivo (N=11)) acts as a miR-589-3p sponge to relieve FGF9➡️⏬CRC apoptosis

Hi circ76691➡️⏬#DiseaseFreeSurvival (TCGA CRC)

#NoncodingRNARes 2025
www.sciencedirect.com/science/arti...

Cyst(e)ine in nutrition formulations promotes colon cancer growth and chemoresistance by activating mTORC1 and scavenging ROS.
Metabolism shapes therapeutic response.
doi.org/10.1038/s413...
#ColonCancer #CancerMetabolism #mTORC1 #ReactiveOxygenSpecies #Chemoresistance #TumorMetabolism

Synergistic Effects of Glutamine Deprivation and Metformin in Acute Myeloid Leukemia

#Glutamine deprivation + metformin treatment inhibits AML cell proliferation & triggers #Apoptosis by suppressing mTOR signaling & increasing ROS levels, suggesting a dual metabolic targeting strategy to overcome #Chemoresistance.

Read: doi.org/10.1007/s115...

#Pericrine #Glioblastoma #Chemoresistance

Pericyte CCL5▶️Tumor cell CCR5▶️ ⏫#DNADamageRepair

Pericyte ablation or Maraviroc (CCR5i) sensitize Glioblastoma xenograft to Temozolomide

Apoptotic tumor cell⏫with distance to pericyte in recurrent glioblastoma

#CellRes 2021
www.nature.com/articles/s41...

Nuclear translocation of #TLR3 in #PancreaticDuctalAdenocarcinoma under #chemotherapy stress drives invasion, proliferation & #chemoresistance via JAK1/PRMT5/c-Myc axis, predicting poor prognosis and highlighting a novel therapeutic target in #cancer.

#STTT: doi.org/10.1038/s413...

Dysadherin/YAP axis fuels stem plasticity and immune escape in liver cancer

This #STTT study reveals that the dysadherin/YAP axis drives stem cell plasticity and immune escape in #HCC via CD24 upregulation, highlighting it as a promising #TherapeuticTarget for overcoming #Chemoresistance.
#OpenAccess: doi.org/10.1038/s413...

#YTHDF1 drives #ColorectalCancer stemness, #tumorigenesis, and #chemoresistance by enhancing m6A-dependent #NOTCH1 translation, while its inhibition suppresses #tumor growth and improves chemotherapy response.

#OpenAccess in #STTT: doi.org/10.1038/s413...

Inhibition of FOS‐Like Antigen 1 Reduces Chemoresistance to Temozolomide Through Stemness Reprogramming via IL‐6/STAT3Tyr705 Pathway The role of FOSL1 in TMZ response to GBM. FOSL1 enhances TMZ resistance by promoting cell cycle progression, MGMT expression, and IL-6-pSTAT3Tyr705-stemness axis. VEM is a potential candidate drug fo...

#Article in #MedComm
Inhibition of FOS-Like Antigen 1 Reduces #Chemoresistance to #Temozolomide Through #Stemness Reprogramming via IL-6/STAT3Tyr705 #Pathway

doi.org/10.1002/mco2...

#FOSL1 #TMZ #Glioblastoma #IL_6 #STAT3

Scientists show that MTFR1 drives #BreastCancer growth via DRP1‑dependent mitochondrial fission & AKT/mTOR signaling, promotes #chemoresistance by altering #apoptosis and #CancerStemness, and identifies the MTFR1/DRP1 axis as a predictive #biomarker.

#OpenAccess: doi.org/10.1016/j.ge...

Scientists identify PKMYT1 as a regulator of #cisplatin sensitivity in #osteosarcoma, showing that PKMYT1‑induced NPM1 S260 phosphorylation enhances #DNARepair and drives #chemoresistance, while combining cisplatin with RP6306 overcomes resistance.

#STTT: doi.org/10.1038/s413...

The m6A reader #YTHDF1 drives #ColorectalCancer stemness, #tumorigenesis, and #chemoresistance by binding #m6A‑modified #NOTCH1; targeting YTHDF1 improves #chemotherapy efficacy, offering a promising therapeutic strategy. #medsky

#OpenAccess in #STTT: doi.org/10.1038/s413...

Treatment Outcome and Chemoresistance-Related Factors of Low-Risk Gestational Trophoblastic Neoplasia: Results From a Tertiary Care Center in Saudi Arabia | JCO Global Oncology PURPOSEGestational trophoblastic neoplasia (GTN) is a highly curable malignancy classified using the International Federation of Gynecology and Obstetrics (FIGO)/WHO scoring system into low-risk (scor...

Pacientes con neoplasia trofoblástica gestacional FIGO 5-6 y hCG elevada tienen una resistencia elevada a la terapia de primera línea por lo que habría que reevaluar las estrategias de tratamiento para este subgrupo #GTN #chemoresistance ascopubs.org/doi/full/10....

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#Stomach #cancer cells can outsmart #chemotherapy! 🧬 TGFB1 ramps up #autophagy through MRAS, making cells resistant to oxaliplatin. Targeting this pathway could make treatment more effective. #StomachCancer #ChemoResistance
🔗 doi.org/10.1139/bcb-...

TLR3 nuclear translocation during chemotherapy stress contributes to cancer #metastasis and #chemoresistance via the JAK1/TLR3/PRMT5/c-Myc axis, which may serve as potential prognostic indicators & targets to overcome chemoresistance.

#STTT #OpenAccess: doi.org/10.1038/s413...

Researchers identify PKMYT1 as a key driver of #cisplatin resistance in #osteosarcoma, showing that PKMYT1-mediated NPM1 phosphorylation disrupts #DNARepair & that inhibiting PKMYT1 with RP6306 synergizes with cisplatin to overcome #chemoresistance.

#STTT: doi.org/10.1038/s413...

Increased TLR3 nuclear translocation during #chemotherapy stress contributes to #metastasis and #chemoresistance via the JAK1/TLR3/PRMT5/c-Myc axis, which may serve as potential targets for predicting chemotherapeutic efficacy & #prognosis. #medsky

#OpenAccess: www.nature.com/articles/s41...

New strategy doubles chemo effectiveness in treatment-resistant cancer Restoring cellular memory prevents cancer cells’ ability to adapt to evade treatment

New strategy doubles chemo’s punch in treatment-resistant cancer. By restoring cellular memory, scientists block cancer cells from dodging treatment like slippery villains in a spy film.
Game-changer?
#TCSC #CancerResearch #ChemoResistance #OncologyBreakthrough

news.northwestern.edu/stories/2025...

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

👉 buff.ly/4OGCRch

#HGSOC #Chemoresistance

#Salidroside (SAL) attenuates #Paclitaxel (PTX) resistance in PTX-resistant #NSCLC cells, in vitro and in tumor-bearing mice in vivo by modulating the Wnt/β-catenin signaling pathway. #LungCancer #Chemoresistance #DrugResistance #medsky

Read: link.springer.com/article/10.1...

Synapse: Your Connection to our MSK Authors:
Meet: Guido Dalbagni
Research Focus - SURGERY; Urology

Natural history and genomic landscape of chemotherapy-resistant muscle-invasive bladder cancer
#BladderCancer #GenomicLandscape #Chemoresistance #Oncology #MIBC

synapse.mskcc.org/synapse/peop...

Nuclear Focal Adhesion Kinase Protects against Cisplatin Stress in Ovarian Carcinoma Abstract. Tumor chemotherapy resistance arises frequently and limits high-grade serous ovarian cancer (HGSOC) patient survival. Focal adhesion kinase (FAK) is an intracellular protein–tyrosine kinase ...

A great new paper from UCSD scientists @ucsandiego.bsky.social has uncovered a novel mechanism of chemotherapy resistance in high-grade serous ovarian cancer (HGSOC) involving Focal Adhesion Kinase (FAK). #ovariancancer #chemoresistance #FAK
doi.org/10.1158/2767...