This review maps the genetic landscape of #AnaplasticThyroidCancer, spotlighting #MAPK & PI3K-AKT-mTOR signaling to connect pathogenic mechanisms with advances in targeted therapies, #immunotherapies, and diagnostic development.

#OpenAccess: doi.org/10.1016/j.ge...

Study Identifies New Potential Therapeutic Target in PPF Piezo1 regulates the p38/ERK-MAPK signaling pathway, thereby inhibiting the endothelial-to-mesenchymal transition and reducing pulmonary fibrosis, research shows.

The Piezo1 protein regulates the p38/extracellular signal-regulated kinase (ERK)-mitogen-activated protein kinase (#MAPK) signaling pathway via the Ca2+/calpain axis, according to a new study published in Cell Communication and Signaling.

Read more: https://bit.ly/4bUiwVy

Identification and Validation of SLC9A2 as A Potential Tumor Suppressor in Colorectal Cancer: Integrating Bioinformatics Analysis with Experimental Confirmation

Bioinformatic and experimental analyses reveal #SLC9A2 as a #TumorSuppressor in #ColorectalCancer, inhibiting proliferation and metastasis via #MAPK signaling, highlighting its potential as a diagnostic and therapeutic target.
Read: doi.org/10.1007/s115...

Rice blast pathogen effector AvrPib compromises disease resistance by targeting Raf‐like protein kinase OsMAPKKK72 to inhibit MAPK signaling The rice Raf-like protein kinase OsMAPKKK72 acts as a scaffold to modulate MAPK signaling. To invade rice plants, the blast fungus delivers the effector AvrPib to target OsMAPKKK72, suppressing MAPK ...

🌾 💥 In this #OpenAccess report, Wang et al. reveal the roles of OsMAPKKK72 in #rice blast resistance and uncover a mechanism by which AvrPib suppresses blast resistance by interfering with #MAPK activation.

doi.org/10.1111/jipb...
@wileylifesci.bsky.social
#PlantScience #MPMI

Get up to speed quickly on your cell biology knowledge with Bioss Pathway Maps

Hand-drawn by a scientific team #Autophagy, #Tumor #Immunology, #MAPK, #WNTSignaling and many others are available to download, print and share at your convenience
👉https://www.stratech.co.uk/our-partners/bioss/#pathways

So excited to see this. Investment in small molecule drugs targeting #Noonansyndrome #RASopathy #RAS #MAPK signaling.
By far the most common gene mutated in #Noonan syndrome is PTPN11 encoding SHP2 protein tyrosine phosphatase. Congrats to Think Biosci.
🧪💊🧬🩺

Ramalin Ameliorates Alzheimer's Disease Pathology by Targeting BACE1, HDAC6, and MAPK Pathways Ramalin alleviates Alzheimer's disease pathology by selectively inhibiting HDAC6, reducing BACE1 levels, and suppressing neuroinflammation through downregulation of the NLRP3 inflammasome and iNOS. I...

#Article in #MedComm

Ramalin Ameliorates #Alzheimer's Disease Pathology by Targeting #BACE1, #HDAC6, and #MAPK Pathways doi.org/10.1002/mco2...

#Ramalin restores synaptic function impaired by #Aβ toxicity and improves cognitive performance in #AD mouse models.

#NLRP3

Loss of #ArylHydrocarbonReceptor drives resistance to BRAFV600E/MEK therapy in #ThyroidCancer via SMAD2/3–ARNT and #TGFβsignaling, positioning AhR as a key regulator of #MAPK inhibitor escape. @uclacollege.bsky.social

#CoverPage in #STTT: doi.org/10.1038/s413...

Antibodies.com | Antibodies, Proteins, and ELISA Kits Antibodies.com supplies high-quality antibodies, proteins, and ELISA kits to life science researchers at cost-effective prices. Discover more, for less.

Persister cells reactivated multiple signaling survival pathways, including #MAPK, #PI3K/ #AKT and #mTOR. #CDK1 activity increased markedly, and inhibiting CDK1 significantly reduced persister cell survival and regrowth.

Ubiquitin-specific protease 13 promotes colorectal cancer progression by stabilizing mitogen-activated protein kinase kinase 3 - Molecular Biomedicine The deubiquitinase ubiquitin-specific protease 13 (USP13) has been implicated in various cancers, yet its precise molecular function and clinical significance in colorectal cancer (CRC) remain poorly ...

#Research
Ubiquitin-specific protease 13 promotes colorectal cancer progression by stabilizing mitogen-activated protein kinase kinase 3 doi.org/10.1186/s435...

#ColorectalCancer #USP13 #MKK3 #P38 #MAPK #signaling #Deubiquitination #TumorProgression

🌟 BlueSky trending hashtags (1h):

#booksky #art #gamedev #pedsky #birds #indiedev #photography #raredisease #noonansyndrome #neurosky #mapk #ras #rasopathies #furry #medsky

🔥 BlueSky trending hashtags (30m):

#booksky #art #birds #pedsky #gamedev #photography #noonansyndrome #neurosky #mapk #ras #rasopathies #raredisease #indiedev #furry #medsky

🚀 BlueSky trending hashtags (15m):

#booksky #art #pedsky #gamedev #noonansyndrome #neurosky #mapk #ras #rasopathies #birds #raredisease #indiedev #photography #furry #furryart

🚀 BlueSky trending hashtags (15m):

#booksky #art #birds #gamedev #furry #photography #raredisease #furryart #mapk #neurosky #ras #rasopathies #noonansyndrome #pixelart #pedsky

Noonan syndrome is a RASopathy characterised by short stature, heart disease and brain-related disorders. Brain-related disorders include intellectual developmental disorder (IDD), autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD), among others. IDD, ASD and ADHD were estimated to affect 23%, 11% and 31% of individuals, respectively. This is higher than the prevalence in the general population. The prevalence of seizure disorders and emotional disorders was also high, although the evidence was more limited.

Prevalence of neurodevelopmental and psychiatric disorders in Noonan syndrome: a systematic review and meta-analysis
#rasopathies #raredisease #noonansyndrome #RAS #MAPK
🧪 🧠 #neurosky #pedsky #medsky
pubmed.ncbi.nlm.nih.gov/41310115/

🔥Hot Off the Press | #Nature: MAPK-induced epithelial plasticity is associated with #CRC therapeutic resistance
🔸Approaches designed to control stem cell fate and #epithelial plasticity, or target #tumors with limited heterogeneity could improve therapeutic effectiveness.
#MAPK

These findings reveal a previously unrecognized regulatory mechanism within the #MAPK pathway, broaden our understanding of post-translational control in cancer biology and may inform future therapeutic strategies.

Using #Multiomics pathway analysis, researchers uncovered how #MAPK pathway activation drives OIS and SASP in a KIAA1549::BRAF fusion #pLGG model, revealing new therapeutic avenues for these #Tumors. #medsky

Read this #STTT #OpenAccess: doi.org/10.1038/s413...

Comprehensive review of multiomics applications and remediation of plant heavy metal toxicity - Stress Biology Heavy metal pollution severely impacts plant health by inhibiting growth, photosynthesis, enzyme activities, and causing oxidative stress. Plants respond to such stress by activating complex defense m...

Comprehensive review of multiomics applications and remediation of plant heavy metal toxicity
Tamana Khan, Labiba Shah ... Faheem Shahzad Baloch, Sheikh Mansoor

link.springer.com/article/10.1...

#MAPK #multiomics #hormone

This review explores the #MolecularMechanisms and #therapeutic advances in #AnaplasticThyroidCancer, focusing on the #MAPK and #PI3K-#AKT-mTOR pathways, diagnostics, and evolving treatment strategies. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Fibroblast Growth Factor Signalling in Development, Health & Disease Conference | Fusion Conferences Receptor Tyrosine Kinases (RTKs) are cell-surface receptors that, upon ligand binding, regulate cell-to-cell communication during embryonic development and in adult life. Among RTKs, the twenty-two Fi...

Excited to join the Fusion Conference on Fibroblast Growth Factor Signalling this May in Malta 🇲🇹!
I’ll be discussing how FGF–MAP kinase signaling unfolds at the single-cell level — bridging molecules to cell decisions 🔬✨
#FGF #MAPK #conference www.fusion-conferences.com/conference/195

So for >30y, it was thought that #MAPK cascade in #fission #yeast lacked a scaffold ! Like in #animals, or #budding yeast.

Well this changes today !

All hail #Sms1

Congrats @borissieber.bsky.social @sophiemartinlab.bsky.social and Team !!

📚 Don't forget to add this Review to your reading list

Specificity models in MAPK cascade signaling

✅plant pathways sharing #MAPK cascade components
✅comparison of mechanisms with animals & yeast

🔓https://buff.ly/3qY5fqk
👩‍🔬 @yanma-fungalls.bsky.social

#PlantSci #CancerSignaling #PlantBiology

This study presents the first multi-omics dataset of a patient-derived pLGG cell line under #MAPK inhibition, revealing MAPK-OIS-SASP signatures, and insights that may guide personalized strategies for #PediatricBrainTumors. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

Diagram of a wheat plant cell cross-section. On the left side of the cell, the TaMAKK2-TaMAPK6 kinase cascade phosphorylates the core immune regulator TaSGT1 and promotes its nuclear entry, contributing to resistance to stripe rust; on the right, an effector from the fungal pathogen that causes stripe rust targets and blocks this process.

🛡️Understanding #plant – #pathogen interactions helps protect crucial #food #crops.
This #MAPK signaling cascade contributes to #wheat stripe rust resistance, providing insights into crop immunity and #fungal #pathogenicity.
doi.org/10.1111/jipb...
#PlantScience #PlantImmunity

Don’t miss this interview with Dr. Ángel R. Nebreda on how cells decode signals, the role of p38 #MAPK in #cancer—and what this has to do with Bosch’s Garden of Earthly Delights. A must-watch for #CancerResearch enthusiasts!

👉 https://youtu.be/wdNqcdu6_bs

#MeettheScientist #OncoSky #SciComm

🧪

RAS isn't just a cancer gene! Learn more about conditions linked to altered #RAS #MEK #MAPK signaling? The "RASopathies" are among the largest group of systemic congenital disorders. See how variants in RAS pathway components affect human development & biology. 🧪
#cansky #oncosky #pedsky #devsky

ClinGen #RASopathy VCEP updates ACMG/AMP variant guidelines, enhancing classification for dominant and recessive RASopathies with broader applications to rare disease genomics bit.ly/3H0AF7s #GIMO #VariantInterpretation #MAPK #Noonan #ACMG #AMP #GeneticDiagnosis #ClinGen

Don't look away when reading about the #MAPK signaling pathway. You'll never be able to find your place again.
#MEKERKRASRAF

📊 Other Highlights
✅ 85% DCR and tolerable safety profile (27.7% grade 3-4 TRAEs)
✅ Acquired alterations included #RTK amplifications/fusions, #EGFR amplification, secondary mutations in KRAS, KRAS amplification, and mutations/fusions in other #MAPK pathway genes.

#Onco404 #Cancer #Kanser #MedSky