Key Insights:
✅ Protein overload in #TumorMicroenvironment induces #TEMRA differentiation 🧫
✅ Activates #UPR (unfolded protein response) leading to T cell senescence ⚠️
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Hashtag
#Tumormicroenvironment
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A novel small-molecule inhibitor of IRF4 selectively suppresses multiple myeloma
G1126, a novel #IRF4 inhibitor, shows potent #AntiMyeloma activity by suppressing #TumorGrowth, targeting drug-resistant progenitor cells, and disrupting #TumorMicroenvironment proliferation, advancing therapy in #MultipleMyeloma.
#OpenAccess: doi.org/10.1016/j.ge...
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Circulating EMID2 as a Prognostic Biomarker of Poor Outcomes in Patients with Metastatic Colorectal Cancer
@biomarkerinsights.bsky.social
@journals.sagepub.com
journals.sagepub.com/doi/10.1177/...
#tumormicroenvironment #cancerdetection #oncology #openaccess
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✅ Highlights dual roles in both #TumorCells and #ImmuneCells within the #TumorMicroenvironment 🧫🛡️
✅ Explores how #MLN4924 (NAE inhibitor) impacts cancer therapy but faces resistance challenges 💊⚠️
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The dysadherin/CA9 axis shapes an acidic tumor microenvironment to promote colorectal cancer progression.
Microenvironmental acidity as a driver of malignancy.
doi.org/10.1038/s413...
#ColorectalCancer #TumorMicroenvironment #CA9 #Dysadherin #TumorAcidity #CancerProgression
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Long noncoding RNA TUG1 promotes chondrosarcoma progression while driving M2 macrophage polarization.
#TUG1 #lncRNA #Chondrosarcoma #M2Polarization #TumorMicroenvironment #BoneCancer
www.sciencedirect.com/science/arti...
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Boosting pancreatic cancer chemotherapy via nerve–cancer crosstalk
www.scienceopen.com/hosted-docum...
#PancreaticCancer #Chemotherapy #TumorMicroenvironment #Neurobiology #CancerTherapeutics
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This review highlights aberrant #neddylation as a driver of #HepatocellularCarcinoma, influencing infection, #tumor growth, invasion, and the #TumorMicroenvironment, while assessing inhibitors like MLN4924 & TAS4464 as promising #HCC therapies.
#OpenAccess: doi.org/10.1016/j.ge...
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This review highlights #HER3 as a key #oncogenic driver shaped by #TumorMicroenvironment signals, stressing the need for predictive #biomarkers, novel ADCs, and combination strategies to boost HER3-targeted #cancer therapies. @cwru.bsky.social
#OpenAccess: doi.org/10.1016/j.ge...
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This review shows how #RNAbindingProteins and #circularRNAs form regulatory networks driving #tumor traits like #metastasis & #DrugResistance, offering therapeutic insights via RNA technologies to reshape the #TumorMicroenvironment.
#OpenAccess: doi.org/10.1016/j.ge...
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Preprint alert! 🚨
www.preprints.org/manuscript/2...
High-grade soft tissue sarcomas (STS) lack robust biomarkers—but we may have a new signal.
#Sarcoma #Immunology #CancerResearch #TumorMicroenvironment #Biomarkers #Oncology
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IL-7 agonist #EfineptakinAlfa (NT-I7) reshapes the #TumorMicroenvironment, expanding T, B, DC, and stem-like CD8 T cells while inducing TLS-like aggregates enriched in PD-L1, suggesting synergy with #PD1blockade.
#OpenAccess: doi.org/10.1016/j.ge...
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Researchers @roswellpark.bsky.social show that the #Exocyst complex mediates fungal-induced IL-33 release from #Cancer cells, identifying a novel secretory mechanism that links fungal-induced immune signaling to #TumorMicroenvironment modulation.
#OpenAccess: doi.org/10.1038/s413...
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This #STTT study introduces a bimetallic nanobomb that activates the STING pathway and boosts BiTEs-mediated #PhotothermalTherapy, effectively remodeling the #Immunosuppressive #TumorMicroenvironment in #ColorectalCancer.
#OpenAccess: doi.org/10.1038/s413...
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🚨 Few spots left!
Join the 7th International Conference on #Cytokines in #Cancer
📅 May 17–22, 2026
📍 Sissi, Crete, Greece
Topics: cytokines & cell communication, inflammation and cancer, #tumormicroenvironment, #irAEs, and therapies.
Register: www.aegeanconferences.org/src/App/conf...
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Weekly reads 23/2/26:
When context controls cancer: oxygen, space, niches and chromatin
open.substack.com/pub/behindth...
Cancer isn’t just mutations: it’s metabolism, space, niches, and chromatin.
#CancerResearch #SingleCell #SpatialBiology #TumorMicroenvironment #PrecisionOncology
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🎉 Excited to share our cover article in Cancer Research!
We identified distinct tumor‑immune ecologies in lung cancer that predict immunotherapy response—moving beyond single biomarkers to spatial interactions. #CancerResearch #Immunotherapy #TumorMicroenvironment #Biomarkers
Paper: t.co/cLLk8JX4UH
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CANCER METABOLISM REVIEW: Metabolic permissiveness: how tissue context shapes cancer
By Chrysanthi Moschandrea and Christian Frezza
➡️ https://genesdev.cshlp.org/content/40/5-6/287.full
Christian Frezza CECAD Cologne Universität zu Köln
#cancermetabolism #tumormicroenvironment
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Last week, CSI Singapore hosted Prof. Hiroyoshi Nishikawa from National Cancer Center (NCC) Japan. He spoke on the topic “Immuno-genomic Analysis Elucidates Immunosuppressive Mechanisms in the Tumor Microenvironment”.
#tumormicroenvironment #cancerimmunology #Immunogenomics #cancerresearch
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Using integrated #scRNAseq, #Immunofluorescence, and functional validation, this study shows that the #Immunosuppressive #TumorMicroenvironment contributes to tumor aggressiveness in lymphovascular invasion-positive #PDAC.
#OpenAccess: doi.org/10.1016/j.ge...
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This review provides insights into #Epigenetic alterations in #Cancer and the #TumorMicroenvironment, outlining their roles in tumor progression and the therapeutic potential of epigenetic drugs and combination strategies.
#OpenAccess: doi.org/10.1016/j.ge...
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New research has revealed that certain #nerves involved in the body’s “fight or flight” #StressResponse can support the growth of #PancreaticCancer.
#SympatheticNerves #TumorGrowth #TumorMicroenvironment
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This #STTT study identified glycolytic heterogeneity within the #PDAC #TumorMicroenvironment and proposes a novel glycolysis-based framework for patient stratification to guide personalized medicine & #PrecisionOncology.
#OpenAccess: doi.org/10.1038/s413...
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Thanks to Gertraud Orend for a great #seminar today! Her talk highlighted that targeting tenascin-C in the #TumorMicroenvironment can improve #therapy responses.
#CancerResearch @3r-network-bw.bsky.social
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The dysadherin/CA9 axis shapes an acidic tumor microenvironment to promote colorectal cancer progression.
Microenvironmental acidity as a driver of malignancy.
doi.org/10.1038/s413...
#ColorectalCancer #TumorMicroenvironment #CA9 #Dysadherin #TumorAcidity #CancerProgression
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Inhibin beta A drives colorectal cancer progression through macrophage M2 polarization and mitochondria-dependent ferroptosis suppression.
Tumor–immune crosstalk meets cell death control.
doi.org/10.1038/s413...
#ColorectalCancer #TumorImmunology #Ferroptosis #TumorMicroenvironment
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Graphical summary of SMLR1 in colorectal cancer liver metastasis. Primary colon tumor cells metastasize to the liver, where SMLR1 expression increases. SMLR1 interacts with macrophage receptors MRC1 (CD206) and SIGLEC1 (CD169), promoting macrophage polarization toward an immunosuppressive, pro-tumoral phenotype. The diagram highlights immune suppression and enhanced tumor growth within the liver-specific metastatic niche.
📖 Commentary Spotlight
In the inaugural issue, Liu discusses how SMLR1 reshapes the liver metastatic niche through macrophage polarization, highlighting its role in cancer plasticity and immune modulation.
🔗 www.pivotscipub.com/chp/1/1/0002...
#CancerHeterogeneity #TumorMicroenvironment
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Graphical abstract illustrating colorectal cancer liver metastasis. Cancer cells in the colon metastasize to the liver, where they upregulate SMLR1. SMLR1 interacts with macrophage receptors MRC1 (CD206) and SIGLEC1 (CD169), promoting tumor–macrophage interactions within the liver microenvironment. Legend indicates cancer cells (green), macrophages (beige), and molecular interactions.
📘 CHP Archive Spotlight #02
Original Research (2024) | Wong et al.
📢 New mechanistic insight in CRC liver metastasis:
Cancer cells upregulate SMLR1 to engage immunosuppressive TAMs, reshaping the liver niche.
🔗 www.pivotscipub.com/chp/1/1/0003...
#ColorectalCancer #TumorMicroenvironment
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#Hypoxia-driven antigen loss and #VEGF secretion drive resistance to MUC16-targeted BITEs in #OvarianCancer, while VEGF blockade restores #cytotoxicity, highlighting #TumorMicroenvironment targeting to boost BITE immunotherapy. @harvardmed.bsky.social
#STTT: doi.org/10.1038/s413...
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Don't miss her talk!
🗓 When: June 28 – July 1, 2026
📍 Where: Salt Lake City, Utah
👉 Become a member & Save: metastasis-research.org/membership-a...
#MRS2026 #EvanthiaRoussosTorres #BreastCancer #Immunotherapy #TumorMicroenvironment #Metastasis #USC #WomenInScience
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