#NucleicAcidsResearch #Epigenetics #Adipocytes #Metabolism #UCP1 #SUMOylation
@ncmbm.bsky.social
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#sumoylation
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This review shows how dysregulated #SUMOylation drives #glioblastoma aggressiveness via #cellcycle, AKT, #microRNAs & #DNARepair, highlighting Ubc9/SAE1 as targets and SUMO inhibitors as promising strategies against proliferation & resistance.
#OpenAccess: doi.org/10.1016/j.ge...
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This letter reports that the #SUMOylation inhibitor TAK‑981 downregulates #MYC, induces #apoptosis, and enhances CD19 CAR‑T efficacy in #BurkittsLymphoma, highlighting SUMOylation inhibition as a promising adjunct strategy.
#OpenAccess in #STTT: doi.org/10.1038/s413...
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A novel PTM 'switch' involving the decrotonylation of Ku80 K568 by HDAC8 enabling its subsequent #SUMOylation by CBX4, drives DNA-PK complex assembly & #DoubleStrandBreak repair to promote #Radioresistance in malignancies.
#OpenAccess: doi.org/10.1038/s413...
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#Research
Sentrin‐specific protease 3 (SENP3)-mediated Krüppel-like factor 4 (KLF4) deSUMOylation regulates vascular smooth muscle cell phenotypic switching in atherosclerosis doi.org/10.1186/s435...
#SENP3 #KLF4 #SUMOylation #PhenotypicSwitching #Atherosclerosis
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Death-associated protein kinase 1-dependent SENP1 degradation increases tau #SUMOylation and leads to cognitive dysfunction in a mouse model for #tauopathy
Xindong Shui...Dongmei Chen, Tao Zhang, Tae Ho Lee #AlzheimersDisease
molecularneurodegeneration.biomedcentral.com/articles/10....
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#SUMOylation and an ATS1 variant converge to disrupt PIP₂-dependent gating of Kir2.1, say Aishwarya Chandrashekar, Leigh Plant and colleagues @nubouve.bsky.social: rupress.org/jgp/article/...
#Pathophysiology #IonChannels #SignalTransduction #CellularPhysiology #MolecularPhysiology
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#SUMOylation inhibitor TAK-981 suppresses #BurkittsLymphoma (BL) and enhances #CD19 #CARTcell therapy by promoting Th2 polarization and boosting #cytotoxicity, highlighting the potential of SUMOylation blockade to overcome refractory BL.
#OpenAccess #STTT: doi.org/10.1038/s413...
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In @jgp.org, Chandrashekar, Plant et al. @nubouve.bsky.social shows that #hypoxia-induced #SUMOylation and the Andersen-Tawil syndrome type 1-linked Kir2.1 mutation, R67Q, converge to impair channel function by destabilizing interactions with PIP₂. rupress.org/jgp/article/...
#IonChannels
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Chandrashekar, Plant et al. @nubouve.bsky.social shows that #hypoxia-induced #SUMOylation and the Andersen-Tawil syndrome type 1-linked Kir2.1 mutation, R67Q, converge to impair channel function by destabilizing interactions with PIP₂. rupress.org/jgp/article/...
#IonChannels
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Mechanistic insights into how the dynamic conversion of Ku80 K568 PTM from crotonylation to #SUMOylation regulates DNA-PK complex & #NHEJ initiation to promote DNA double-strand break repair and tumor #Radioresistance. #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
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This recent review delves into #SUMOylation, which affects the #CellCycle, PKB/AKT signaling, and miRNA expression in #Glioma, and spotlights #Ubc9, which enhances #Tumor pathogenesis, as an emerging #therapeutic target for #Glioblastoma. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...
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This research identifies #SMAD4 #SUMOylation as a critical molecular switch in lens fibrosis and highlights SUMO inhibitors as potential novel therapeutic strategies against #Fibrotic #Cataracts. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...
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New publication @chymkowitchlab.bsky.social about how #IRX3 regulates adipocyte fate by influencing #epigenetic reprogramming, through modulating #SUMOylation and #chromatin remodeling, impacting fat storage and mesenchymal identity while suppressing osteogenesis.
Published in @natcomms.nature.com
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IRX3 buffers the SUMOylation to promote adipogenesis and block osteogenesis. IRX3 loss boosts SUMOylation, inhibits PPARγ, and pushes cells toward bone fate, which is reversible with SUMOylation inhibition.
IRX3 is an epigenetic gatekeeper.
#Epigenetics #Adipogenesis #ObesityRisk #SUMOylation
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📢Welcome to read: Evaluating Protein Extraction Techniques for Elucidating #Proteomic Changes in #Yeast Deletion Strains, by Valentina Rossio and @jpaulo.bsky.social.
See details at mdpi.com/2227-7382/13/3/28
@harvardmed.bsky.social
#proteomes #proteomics #proteoforms #SUMOylation #OpenAccess
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ℹ️ Don't miss our new Commentary
Small modifier, big decision: switching to SUMO mode adds weight to cancer stemness in mammary tumors
➡️ buff.ly/ZscdSzr
#Sumoylation #CancerStemness #BCSM
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Trying to understand the role of the sumoylation pathway in a possible new neurodevelopmental disorder.
If someone who is an expert on this pathway and is willing to help me, please reach out! I'll be forever grateful 🥹🧬🔬
#sumoylation #ndd #newgene #novelndd #SUMO #sumoylationpathway
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Can targeting #SUMOylation open new doors in #OvarianCancer treatment? 🔍🧬
New #iScience study screened 30 patient-derived models — finding #MYC sensitivity & #ABCB1 resistance. A step toward #PersonalisedMedicine 💡
🧾 www.sciencedirect.com/science/arti...
#CancerResearch #TargetedTherapy #Drug
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We are extending the application deadline for this post-doc position! Do not miss the opportunity to join an exciting project in a dynamic and collaborative research environment. @igbmc.bsky.social @pasteur.fr @univbordeaux.bsky.social @uio.no #epigenetics #cellfate #SUMOylation @ncmbm.bsky.social
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Nuclear pore complex protein RANBP2 and related SUMOylation in solid malignancies
This review explores in detail the significance of #RANBP2, a lesser-known SUMO E3 ligase & #NuclearPoreComplex protein, across various malignancies and highlights its potential as a prospective therapeutic target for #cancer treatment. #SUMOylation #Epigenetics #medsky
#OpenAccess: buff.ly/J4BZsEe
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We were interested in trying to understand the mechanisms by which cellular stress regulates #TDP43 and how these pathways may contribute to sporadic forms of neurodegeneration including #ALS and #FTD. We hypothesized that #SUMOylation may play a role.
🔬Here’s what we found:
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New publication: These findings provide evidence that #SUMOylation is essential for fat accumulation in vivo.
With Xu Zhao, Patrizia Nothnagel & P. Chymkowitch @chymkowitchlab.bsky.social from @biovitenskap.bsky.social
Published by @tandfresearch.bsky.social
www.tandfonline.com/doi/full/10....
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As TAK-981 is in clinical trial for cancer, these findings highlight the need to consider its potential metabolic effects.
Nice collaboration between my group at @uio.no @biovitenskap.bsky.social, Antoine Martinez @ucauvergne.bsky.social
#Adipogenesis #SUMOylation #Metabolism #InVivo #CancerTherapy
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#SUMOylation bias in #Mitosis! SAE2 deacetylation directs SUMO1 conjugation to support mitotic fidelity, showing a new layer of SUMO regulation. Walker et al 2024, Morris Lab@unibirmingham.bsky.social
#preprintpeerreview by @reviewcommons.org
Reviews here>eeb.embo.org/doi/10.1101/2022.03.18.484840
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Top left: Representative images of the isolated germlines of WT and F2 ulp-2(tv380) animals; the germline zones and sperm are indicated. Scale bar = 30 μm. Insets below the images show magnification of the proximal gonad and sperm. Bottom left: Representative images of UNC-119::GFP localization in WT and F2 ulp-2(tv380) animals. White line marks the proximal gonad, most proximal oocyte (oo) and spermatheca (sp). Right: Model for SET-26 functional dependence on sumoylation. In homeostasis, SET-26 and its interactors bind H3K4me3 marks to regulate gene expression. Unbalanced sumoylation of SET-26 disrupts its reader function by decreasing its binding to H3K4me3 marks. Consequently, germline transcription is perturbed.
ULP-2 is a conserved SUMO protease required for embryonic development in #Celegans, but what does it do? This study shows that ULP-2 controls germline development by regulating #SUMOylation levels (and so activity) of H3K4me3 reader SET-26 🧪 @plosbiology.org plos.io/403ixQ5
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Top left: Representative images of the isolated germlines of WT and F2 ulp-2(tv380) animals; the germline zones and sperm are indicated. Scale bar = 30 μm. Insets below the images show magnification of the proximal gonad and sperm. Bottom left: Representative images of UNC-119::GFP localization in WT and F2 ulp-2(tv380) animals. White line marks the proximal gonad, most proximal oocyte (oo) and spermatheca (sp). Right: Model for SET-26 functional dependence on sumoylation. In homeostasis, SET-26 and its interactors bind H3K4me3 marks to regulate gene expression. Unbalanced sumoylation of SET-26 disrupts its reader function by decreasing its binding to H3K4me3 marks. Consequently, germline transcription is perturbed.
ULP-2 is a conserved SUMO protease required for embryonic development in #Celegans, but what does it do? This study shows that ULP-2 controls germline development by regulating #SUMOylation levels (and so activity) of H3K4me3 reader SET-26 🧪 @plosbiology.org plos.io/403ixQ5
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Top left: Representative images of the isolated germlines of WT and F2 ulp-2(tv380) animals; the germline zones and sperm are indicated. Scale bar = 30 μm. Insets below the images show magnification of the proximal gonad and sperm. Bottom left: Representative images of UNC-119::GFP localization in WT and F2 ulp-2(tv380) animals. White line marks the proximal gonad, most proximal oocyte (oo) and spermatheca (sp). Right: Model for SET-26 functional dependence on sumoylation. In homeostasis, SET-26 and its interactors bind H3K4me3 marks to regulate gene expression. Unbalanced sumoylation of SET-26 disrupts its reader function by decreasing its binding to H3K4me3 marks. Consequently, germline transcription is perturbed.
ULP-2 is a conserved SUMO protease required for embryonic development in #Celegans, but what does it do? This study shows that ULP-2 controls germline development by regulating #SUMOylation levels (and so activity) of H3K4me3 reader SET-26 🧪 @plosbiology.org plos.io/403ixQ5
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🎄 What a fantastic Christmas gift! Our #FRIPRO application on the regulation of epigenetic fate by #SUMOylation has been awarded 12MNOK by the Research Council of Norway!
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1 day left to apply: Available PhD position @DiMeN_DTP @The_MRC
How does #SUMOylation shape nuclear organisation? How does that impact #trypanosome immune evasion.
If you find this an exciting topic, join us! @BiologyatYork @YBRI_UoY & @UoDLifeSciences
For more information, contact me!
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